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Postion:Product Catalog >Biochemical Engineering>Amino Acids and proteins> L-Phenylalanine
L-Phenylalanine
  • L-Phenylalanine
  • L-Phenylalanine

L-Phenylalanine NEW

Price $6 $5 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: L-Phenylalanine CAS No.: 63-91-2
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
Name: Sun

1. Product information

Names

NameL-phenylalanine
SynonymMore Synonyms

 L-Phenylalanine Biological Activity

DescriptionL-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1]Target: Calcium ChannelL-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3].
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Metabolic Disease
Natural Products >> Phenylpropanoids
References

[1]. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41.

[2]. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67.

[3]. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24.

[4]. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7.

[5]. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.

 Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point307.5±30.0 °C at 760 mmHg
Melting Point270-275oC (dec.)(lit.)
Molecular FormulaC9H11NO2
Molecular Weight165.189
Flash Point139.8±24.6 °C
Exact Mass165.078979
PSA63.32000
LogP1.11
Vapour Pressure0.0±0.7 mmHg at 25°C
Index of Refraction1.576

 MSDS

L-Phenylalanine MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • AY7535000

  • CHEMICAL NAME :

  • Alanine, phenyl-, L-

  • CAS REGISTRY NUMBER :

  • 63-91-2

  • LAST UPDATED :

  • 199706

  • DATA ITEMS CITED :

  • 18

  • MOLECULAR FORMULA :

  • C9-H11-N-O2

  • MOLECULAR WEIGHT :

  • 165.21

  • WISWESSER LINE NOTATION :

  • QVYZ1R -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 5287 mg/kg

  • TOXIC EFFECTS :

  • Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >1322 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 276 gm/kg/13W-C

  • TOXIC EFFECTS :

  • Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 220 gm/kg

  • SEX/DURATION :

  • male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 160 gm/kg

  • SEX/DURATION :

  • male 2 week(s) pre-mating female 2 week(s) pre-mating - 8 day(s) post-birth

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - behavioral

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 192 gm/kg

  • SEX/DURATION :

  • male 2 week(s) pre-mating female 2 week(s) pre-mating - 15 day(s) post-birth

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - physical

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 21750 mg/kg

  • SEX/DURATION :

  • female 15-19 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - other effects to embryo

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 30 gm/kg

  • SEX/DURATION :

  • female 10-14 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 7930 mg/kg

  • SEX/DURATION :

  • female 8-11 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 1980 mg/kg

  • SEX/DURATION :

  • female 9 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 2640 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - other effects to embryo

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 6048 mg/kg

  • SEX/DURATION :

  • female 8-11 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Effects on Newborn - biochemical and metabolic

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 30 mg/kg

  • SEX/DURATION :

  • female 3 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - uterus, cervix, vagina

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 33600 mg/kg

  • SEX/DURATION :

  • female 1-24 week(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - behavioral

MUTATION DATA

  • TYPE OF TEST :

  • Sister chromatid exchange

  • TEST SYSTEM :

  • Human Lymphocyte

  • DOSE/DURATION :

  • 10 mg/L

  • REFERENCE :

  • MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5534 No. of Facilities: 792 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 19901 (estimated) No. of Female Employees: 14903 (estimated)

 Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesC: Corrosive;
Risk PhrasesR36/37/38
Safety Phrases22-24/25-37/39-45-36/37/39-27-26
RIDADRNONH for all modes of transport
WGK Germany3
RTECSAY7535000
HS Code29224995

 Synthetic Route

Previous 1/113 Next
Article illustration

3-phenyl-(2S)-[...

1004755-04-7

~47%

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L-Phenylalanine

63-91-2

Literature: Kaneka Corporation Patent: EP2050738 A1, 2009 ; Location in patent: Page/Page column 29-30 ;
Article illustration

(S)-2-hydraziny...

1202-31-9

~97%

Article illustration

L-Phenylalanine

63-91-2

Literature: Trimble, Laird A.; Vederas, John C. Journal of the American Chemical Society, 1986 , vol. 108, # 20 p. 6397 - 6399
Article illustration

N/A

136707-50-1

~76%

Article illustration

L-Phenylalanine

63-91-2

Literature: Williams; Im Journal of the American Chemical Society, 1991 , vol. 113, # 24 p. 9276 - 9286

 Precursor & DownStream

Precursor  6

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  • Article illustration CAS#:150-30-1
    DL-Phenylalanine

  • Article illustration CAS#:55895-88-0
    α-phenylalanine...

DownStream  10

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 Customs

HS Code29224995

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 Synonyms

Benzenepropanethioic acid,S-phenyl ester
(S)-phenylalanine
L-Phenylalanine
EINECS 200-568-1
(2S)-2-amino-3-phenylpropanoic acid
L-PHENYLALININE
α-Amino-β-phenylpropionic acid, L-
H-Phe-OH
Alanine, 3-phenyl-
L-phenylalanine zwitterion
S-phenylalanine
(S)-(-)-Phenylalanine
Thiohydrozimtsaeurephenylester
(S)-a-Amino-b-phenylpropionic Acid
Alanine, phenyl-, L-
L-2-Amino-3-phenylpropionic acid
(S)-2-Amino-3-phenylpropionic acid
(S)-2-Amino-3-phenylpropanoic acid
C6H5CH2CH(NH2)COOH
(S)-a-Aminohydrocinnamic Acid
Phenylalanine
α-Aminohydrocinnamic acid, L-
(L)-Phenylalanine
Phenylalanine (VAN)
Phenylalanine, L-
Benzenepropanoic acid, α-amino-, (S)-
l-Phe
PhE
phenyl 4-phenylthiobutanoate
S-Phenyl-3-phenylpropanthioat
β-phenyl-L-alanine
(-)-Phenylalanine
(S)-α-Aminobenzenepropanoic acid
MFCD00064227
3-Phenylpropionyl-phenyl-thioether
α-Amino-β-phenylpropionic acid
3-Phenylthiopropionic acid,S-phenyl ester
(S)-A-Aminobenzenepropanoic Acid
Acetylcysteine Impurity 3


2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137





Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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