Glutathione NEW

Price	$8	$2	$0.9
Package	1KG	25KG	100KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-29

Product Details

Product Name: Glutathione	CAS No.: 70-18-8
Min. Order: 1KG	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/29
Lead time: In stock	Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express	Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details	Name: Sun

1. Product information

Name	(E,E,E)-geranylgeraniol
Synonym	More Synonyms

Description	Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model[1][2][3][4].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	NF-kB[1]
In Vitro	Geranylgeraniol (0-10 μM; 24 h) dose-dependently suppresses the LPS-induced increase in the mRNA levels of Il-1β, Tnf-α, Il-6, and Cox-2[1]. Geranylgeraniol (10 μM; 24 h) inhibits the phosphorylation of TAK1, IKKα/β, and NF-κB p65 proteins as well as NF-κB nuclear translocation induced by LPS while maintaining IκBα expression[1]. Geranylgeraniol, (50 μM; 24 h) eliminates cell damage caused by Simvastatin (HY-17502) (10 μM) and Mevalonat (10 mM), and reduces the inflammatory marker and the damage of the mitochondria, maintaining its shape and component[2]. Western Blot Analysis[1] Cell Line: MG6 cell Concentration: 0, 1, 10 μM Incubation Time: 24 hours Result: Suppressed by TAK1, IKKα/β, and NF-κB p65 proteins level at 10 μM. RT-PCR[1] Cell Line: MG6 cell Concentration: 10 μM Incubation Time: 0, 6, 12, 24 hours Result: Significantly inhibited pro-inflammatory cytokine Il-1β, Tnf-α, Il-6, and Cox-2 mRNA level.
In Vivo	Geranylgeraniol (725 mg/kg/d; p.o.; 90 d) is not toxicologically significant with a dose below 725 mg/kg/d in rats[3]. Geranylgeraniol (483 mg/kg/d; p.o.; 10 d) suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats[4]. Animal Model: Han Wistar rats (169-192 g for male; 116-152 g for female)[3] Dosage: 0, 725, 1450, and 2900 mg/kg Administration: Oral gavage; once daily; 90 days Result: Showed the lowest observed adverse effect level (LOAEL) for local effects and the no observed adverse effect level (NOAEL) for systemic effects as 725 mg/kg/d. Reduced body weights by 12.9 and 21.6% in the intermediate- and high-dose group males, respectively, compared to controls. Animal Model: Wistar rats (male, 8-week-old, 130-150 g)[4] Dosage: 0, 48.3, 483, 4830 mg/kg Administration: Oral gavage; once daily; 10 days; with or not LPS challenge (i.p.; 0.5 mg/kg) Result: Suppressed LPS-induced inflammatory cytokines and mRNA expression of LPS-induced inflammatory genes in liver with doses of 483 mg/kg and 4830 mg/kg. Suppressed protein levels of IRAK1, TRAF6, and TAK1, originating from transcriptional down-regulation with doses of 483 mg/kg and 4830 mg/kg.
References	[1]. Saputra WD, et al. Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation. Int J Mol Sci. 2021 Sep 29;22(19):10543. [2]. Marcuzzi A, et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. Int J Mol Sci. 2016 Mar 11;17(3):365. [3]. Preece K, et al. A toxicological evaluation of geranylgeraniol. Regul Toxicol Pharmacol. 2021 Aug;124:104975. [4]. Giriwono PE, et al. Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. Eur J Nutr. 2013 Apr;52(3):1191-9.

Density	0.88 g/cm3
Boiling Point	397.1oC at 760 mmHg
Molecular Formula	C₂₀H₃₄O
Molecular Weight	290.48300
Flash Point	128.3oC
Exact Mass	290.26100
PSA	20.23000
LogP	6.12440
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.492
Storage condition	-20°C

GERANYLGERANIOL MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2905290000

ethyl all-trans...

24035-35-6

~95%

GERANYLGERANIOL

24034-73-9

Literature: Crombie, Leslie; McNamara, Desmond; Firth, David F.; Smith, Sue; Bevan, Peter C. Phytochemistry (Elsevier), 1988 , vol. 27, # 6 p. 1685 - 1694

N/A

412348-52-8

~90%

GERANYLGERANIOL

24034-73-9

Literature: Radetich, Branko; Corey Organic Letters, 2002 , vol. 4, # 20 p. 3463 - 3464

N/A

1011505-97-7

~95%

GERANYLGERANIOL

24034-73-9

Literature: Kuk, Jinchul; Beom, Soo Kim; Jung, Heejung; Choi, Seyoung; Park, Jung-Youl; Koo, Sangho Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1991 - 1994

Precursor 4
CAS#:24035-35-6 ethyl all-trans... CAS#:68690-51-7 all-trans-1-ben... CAS#:71816-56-3 (2E,6E,10E)-3,7... CAS#:24163-93-7 (E,E)-3,7,11-tr...
DownStream 10	Previous 1/3 Next
CAS#:107438-44-8 [3-methyl-3-(4,... CAS#:142673-23-2 (3,7,11-trimeth... CAS#:504-96-1 Neophytadiene CAS#:505-32-8 ISOPHYTOL

HS Code	2905290000
Summary	2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells.

PLoS ONE 10 , e0132761, (2015)

The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remain...

PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.

Cancer Cell Int. 15 , 27, (2015)

PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumor...

Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons.

Sci. Rep. 5 , 15960, (2015)

The bipolar spiral ganglion neurons (SGN) carry sound information from cochlear hair cells to the brain. After noise, antibiotic or toxic insult to the cochlea, damage to SGN and/or hair cells causes ...

MFCD00129083

Geranylgeraniol

(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol

all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

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3. Shipping

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4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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