Digitoxin NEW
| Price | $8 | $5 | $1 |
| Package | 1KG | 25KG | 100KG |
| Min. Order: | 1KG |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-09 |
Product Details
| Product Name: Digitoxin | CAS No.: 71-63-6 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/09 |
| NAME: Sun | Origin: By express, by air, by sea |
| Origin: Manufacturer, advantage product | COA, MSDS: Available, contact us for details |
| In stock: bag/bottle/drum/IBC | Lead time: In stock, ready for shipment |
1. Materials information
| Name | digitoxin |
|---|---|
| Synonym | More Synonyms |
| Description | Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM.IC50 value: 0.78 μM (EC50)Target: Na+/K+-ATPasein vitro: Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest, also remarkably activates 5' adenosine monophosphate-activated protein kinase (AMPK). Moreover, Digitoxin suppresses microtubule formation through decreasing α-tubulin. Digitoxin effectively depresses the growth of TKI-resistance NSCLC H1975 cells by inhibiting microtubule polymerization and inducing cell cycle arrest. Digitoxin has the highest cytotoxicity in H1975 cells, whose CC50 value was 0.19 ± 0.06 μM. Digitoxin-induced inhibition mechanism is likely due to causing G2/M cell cycle arrest in H1975 cells in dose dependent manners. |
|---|---|
| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Na+/K+ ATPase Natural Products >> Steroids Research Areas >> Cardiovascular Disease |
| References | [1]. Zhang YZ, et al. Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules. 2016 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 902.3±65.0 °C at 760 mmHg |
| Melting Point | 240oC (dec.)(lit.) |
| Molecular Formula | C41H64O13 |
| Molecular Weight | 764.939 |
| Flash Point | 269.5±27.8 °C |
| Exact Mass | 764.434692 |
| PSA | 182.83000 |
| LogP | 2.44 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.594 |
. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 8613526505137
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- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro