TCO-PEG4-NHS ester manufacturers
- TCO-PEG4-NHS ester
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- $61.00 / 5mg
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2025-05-09
- CAS:1613439-69-2
- Min. Order:
- Purity: 99.49%
- Supply Ability: 10g
- (4E)-TCO-PEG4-NHS ester
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- $0.00 / 50mg
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2024-03-21
- CAS:1613439-69-2
- Min. Order: 50mg
- Purity: >95.00%
- Supply Ability: 50mg
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| | TCO-PEG4-NHS ester Basic information |
| Product Name: | TCO-PEG4-NHS ester | | Synonyms: | TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;(E/Z)-TCO-PEG4-NHS ester | | CAS: | 1613439-69-2 | | MF: | C24H38N2O10 | | MW: | 514.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1613439-69-2.mol |  |
| | TCO-PEG4-NHS ester Chemical Properties |
| density | 1.23±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.95±0.46(Predicted) | | form | Oil | | color | Colorless to light yellow | | InChI | InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- | | InChIKey | ZKPMRASGLDBKPF-UPHRSURJSA-N | | SMILES | C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
| | TCO-PEG4-NHS ester Usage And Synthesis |
| Description | TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition | | Biological Activity | TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target |
| | TCO-PEG4-NHS ester Preparation Products And Raw materials |
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Tag:TCO-PEG4-NHS ester(1613439-69-2)
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