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| | (chlorodifluoroMethyl)triMethylsilane Basic information |
| | (chlorodifluoroMethyl)triMethylsilane Chemical Properties |
| Boiling point | 90.0±40.0 °C(Predicted) | | density | 1.039±0.06 g/cm3(Predicted) | | form | liquid | | color | colorless | | InChI | InChI=1S/C4H9ClF2Si/c1-8(2,3)4(5,6)7/h1-3H3 | | InChIKey | DGLFKUGPLIRHCC-UHFFFAOYSA-N | | SMILES | [Si](C(Cl)(F)F)(C)(C)C |
| Risk Statements | 11 | | Safety Statements | 24/25 | | TSCA | No | | HS Code | 29319090 |
| | (chlorodifluoroMethyl)triMethylsilane Usage And Synthesis |
| Uses | (Chlorodifluoromethyl)trimethylsilane, is one of the partially fluorinated compounds, which are often used for diverse applications in materials science, agrochemistry, and the pharmaceutical industry. | | Uses | (chlorodifluoroMethyl)triMethylsilane，also known as Hu reagent，it can be used to generate difluorocarbene at higher temperatures catalyzed by chloride ion. | | Reactions |
(1) Difluoromethylenation of alkenes.
Refs. 1) Angew. Chem. Int. Ed. 2011, 50, 7153 –7157; 2) Chem. Commun. 2011, 47, 2411–2413.
(2) Difluoromethylenation of alkynes.
Refs. 1) Angew. Chem. Int. Ed. 2011, 50, 7153 –7157; 2) Chem. Commun. 2011, 47, 2411–2413.
(3) Difluoromethylenation of TMSCN.
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(4) Difluoromethylenation of benzyl and alkylzinc halides.
Ref. Org. Lett. 2013, 15, 917 – 919.
(5) Fluorination aminocarbonylation of aldehydes
Ref. Angew. Chem. Int. Ed. 2022, e202115467
| | References |
[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899
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| | (chlorodifluoroMethyl)triMethylsilane Preparation Products And Raw materials |
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