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ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Forensic and veterinary standards >ROLITETRACYCLINE

ROLITETRACYCLINE

ROLITETRACYCLINE Suppliers list
Company Name: Finetech Industry Limited
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Products Intro: Product Name:ROLITETRACYCLINE
CAS:751-97-3
Purity:98% Package:1g,10g,25g,100g,500g,1kg
Company Name: InvivoChem
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Products Intro: Product Name:Rolitetracycline
CAS:751-97-3
Purity:98% Package:5mg Remarks:V11451
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501
Email: product@acmec-e.com
Products Intro: Product Name:Rolitetracycline
CAS:751-97-3
Purity:98% Package:5mg, 10mg
Company Name: Aladdin Scientific
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Products Intro: Product Name:Rolitetracycline
CAS:751-97-3
Purity:>=85% Package:$332.9/5mg;$352.9/25mg;$617.9/100mg;$6175.9/1g;Bulk package Remarks:85%
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
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Products Intro: Product Name:Rolitetracycline
CAS:751-97-3
Purity:0.99 Package:100g;1kg;5KG;1KG
ROLITETRACYCLINE Basic information
Product Name:ROLITETRACYCLINE
Synonyms:12,12a-pentahydroxy-6-methyl-1,11-dioxo-n-(1-pyrrolidinylmethyl)-1;bristacin;n-(1-pyrrolidinylmethyl)-tetracycline;n-(pyrrolidinomethyl)tetracycline;pirrolidinometil-tetraciclina;prm-tc;pyrrolidinomethyl-tetracyclin;pyrrolidino-methyl-tetracycline
CAS:751-97-3
MF:C27H33N3O8
MW:527.57
EINECS:212-031-9
Product Categories:PAVULON
Mol File:751-97-3.mol
ROLITETRACYCLINE Structure
ROLITETRACYCLINE Chemical Properties
Melting point 163.5°C
Boiling point 608.16°C (rough estimate)
density 1.2902 (rough estimate)
refractive index 1.7120 (estimate)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
pkapKa 7.4 (Uncertain)
color Very Dark Red to Very Dark Brown
Water Solubility >20g/L(21 ºC)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS QI9150000
MSDS Information
ROLITETRACYCLINE Usage And Synthesis
DescriptionRolitetracycline was synthesized in 1958. Bristol-Myers Laboratories prepared it from tetracycline by introducing a pyrrolidinylmethyl moiety. This antibiotic is very soluble in water and more stable than tetracycline under acidic conditions. Rolitetracycline is used by intravenous injection, and its nitrate is used by both intravenous and intramuscular injections for therapy of the same infections as those treated by tetracycline.
UsesRolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable.
UsesRolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.
Usesneuromuscular blocker
DefinitionChEBI: A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.
Brand nameSyntetrin (Bristol-Myers Squibb).
General DescriptionRolitetracycline, N-(pyrrolidinomethyl)tetracycline(Syntetrin), was introduced for use by intramuscular or intravenousinjection. This derivative is made by condensingtetracycline with pyrrolidine and formaldehyde in the presenceof tert-butyl alcohol. It is very soluble in water (1 g dissolvesin about 1 mL) and provides a means of injecting theantibiotic in a small volume of solution. It has been recommendedfor cases when the oral dosage forms are not suitable,but it is no longer widely used.
Pharmaceutical Applications2-N-pyrrolidinomethyl-tetracycline. A semisynthetic derivative of tetracycline supplied as the nitrate sesquihydrate for parenteral use.
It is not absorbed from the gastrointestinal tract. It is highly soluble and therefore can be administered parenterally. Peak plasma concentrations of 4–6 mg/L occur at 0.5–1 h after 350 mg intravenously. The plasma elimination half-life is 5–8 h. About 50% of the dose is excreted in the urine, producing high concentrations.
Intravenous administration is occasionally accompanied by abnormal taste, shivering and rigors, hot flushes, facial reddening, dizziness and, rarely, circulatory collapse. Symptoms of myasthenia gravis have occasionally been exacerbated.
ROLITETRACYCLINE Preparation Products And Raw materials
Tag:ROLITETRACYCLINE(751-97-3) Related Product Information
rolitetracycline nitrate technetium Tc 99m rolitetracycline 1,2,3,4-Tetrahydro-1-naphthol 4-Methyl-1-tetralone (S)-2-METHYL-1-PHENYL-BUT-3-EN-1-OL Tetracycline Prolinomethyltetracycline ROLITETRACYCLINE 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL 1-ACETYL-1-CYCLOHEXENE