CPD1599
| 中文名稱 | CPD1599 |
|---|---|
| 中文同義詞 | 化合物 T13602;化合物CDDO-2P-IM;化合物CDDO-2P-IM,10 MM DMSO 溶液 |
| 英文名稱 | CDDO-3-P-Im |
| 英文同義詞 | CDDO-3-P-Im;CPD1599;CPDB1599;CDDO-2P-Imidazolide;Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]-;CDDO-2P-Im, 10 mM in DMSO |
| CAS號(hào) | 1883650-96-1 |
| 分子式 | C39H46N4O3 |
| 分子量 | 618.81 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1883650-96-1.mol |
| 結(jié)構(gòu)式 |  |
CPD1599 性質(zhì)
| 沸點(diǎn) | 766.1±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：250 mg/mL（404.00 mM） |
| 酸度系數(shù)(pKa) | 1.60±0.19(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
CDDO-2P-Im 是 CDDO 咪唑胺類似物，具有化學(xué)預(yù)防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺腫瘤的大小和嚴(yán)重程度。
CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 5.8 nM.
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 30 nM, 100 nM |
| Incubation Time: | 4 days |
| Result: | Induced differentiation of U937 cells at 100 nM. |
CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
| Animal Model: | Seven week-old female A/J mice |
| Dosage: | 50 mg/kg, 200 mg/kg |
| Administration: | Diet; for 16 weeks |
| Result: | Decreased the number, the size and the severity of tumors. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-135953 | CDDO-3P-Im | 1883650-96-1 | 1 mg | 924元 |
| 2025/02/08 | HY-135953 | CPD1599 CDDO-3P-Im | 1883650-96-1 | 5mg | 2475元 |