|
|
| | 1-(Trifluoroacetyl)imidazole Basic information |
| | 1-(Trifluoroacetyl)imidazole Chemical Properties |
| Boiling point | 137 °C(lit.) | | density | 1.442 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.424(lit.) | | Fp | 113 °F | | storage temp. | 2-8°C | | solubility | sol most common solvents, e.g. ether, THF. | | form | clear liquid | | pka | 0.78±0.10(Predicted) | | Specific Gravity | 1.442 | | color | Colorless to Yellow to Orange | | Water Solubility | reacts | | Sensitive | Moisture Sensitive | | BRN | 608904 | | CAS DataBase Reference | 1546-79-8(CAS DataBase Reference) | | NIST Chemistry Reference | N-Trifluoroacetylimidazole(1546-79-8) |
| | 1-(Trifluoroacetyl)imidazole Usage And Synthesis |
| Chemical Properties | Colorless to pink liquid | | Uses | 1-(Trifluoroacetyl)imidazole was used as a derivating agent to sequentially derivatize functional groups like amino groups, in a study demonstrating trimethylsilyl esters of aromatic and aliphatic sulfonic acids. | | Preparation | N,N′-Carbonyldiimidazole (20.5 g) is dissolved in 100 ml of dry THF and treated dropwise with 28.8 g of Trifluoroacetic Acid in 80 mL of dry THF. The resulting solution is cooled for several hours. Removal of the solvent and distillation of the filtrate gives 14.4 g of material. Alternatively, Imidazole (25.8 g) in 120 mL of dried THF is treated dropwise, with cooling, with 39.9 g of Trifluoroacetic Anhydride in 50 mL of dried THF. Filtration, removal of solvent, and distillation gives 24.8 g of 1-(Trifluoroacetyl)imidazole. | | General Description | 1-(Trifluoroacetyl)imidazole is a derivatizing reagent. | | reaction suitability | reagent type: derivatization reagent
reaction type: Acylations | | storage | store under nitrogen, carefully excluding water. Irritant; moisture sensitive; keep cold; flammable. |
| | 1-(Trifluoroacetyl)imidazole Preparation Products And Raw materials |
|