| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:AX 048
CAS:873079-69-7
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:AX 048
CAS:873079-69-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:AX 048
CAS:873079-69-7
Purity:98% Package:500ug; 5mg; 1mg Remarks:Medbio
|
AX 048 manufacturers
- AX 048
-
- $2420.00 / 5mg
-
2024-10-28
- CAS:873079-69-7
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| Product Name: | AX 048 | | Synonyms: | AX 048;FMFKQXKYWWJNJS-UHFFFAOYSA-N;Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester | | CAS: | 873079-69-7 | | MF: | C22H41NO4 | | MW: | 383.57 | | EINECS: | | | Product Categories: | | | Mol File: | 873079-69-7.mol |  |
| | AX 048 Chemical Properties |
| Melting point | 63-64 °C | | density | 0.963±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | pka | 12.25±0.46(Predicted) |
| | AX 048 Usage And Synthesis |
| Uses | AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy[1]. | | in vivo | AX048 (0-30 mg/kg, i.p.) reduces the thermal hyperalgesia with the ED50 of 1.2 mg/kg in Sprague Dawle rats[1]. | Animal Model: | Carrageenan-induced thermal hyperalgesia in Sprague Dawley rats[1] | | Dosage: | 0-30 mg/kg | | Administration: | i.p. | | Result: | Reduced the escape latencies in a dose-dependent manner. |
| | IC 50 | cPLA2 | | References | [1] Yaksh TL, et al., Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan;316(1):466-75. DOI:10.1124/jpet.105.091686 |
| | AX 048 Preparation Products And Raw materials |
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