NETAMIFTIDE
| 中文名稱 | NETAMIFTIDE |
|---|---|
| 中文同義詞 | NEMIFITIDE DITFA;FLUORO-PHE-HYP-ARG-GLY-TRP-NH2;五肽INN 00835;多肽NEMIFITIDE三氟乙酸鹽 |
| 英文名稱 | NETAMIFTIDE |
| 英文同義詞 | Bis(trifluoroacetate);NETAMIFTIDE;(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide;Netamiftide ditriflutate;Nemifitide diTFA;INN 00835 diTFA;Nemifitide di;Nemifitide Ditriflutate |
| CAS號 | 204992-09-6 |
| 分子式 | C35H44F4N10O8 |
| 分子量 | 808.79 |
| EINECS號 | |
| 相關(guān)類別 | 多肽 |
| Mol文件 | 204992-09-6.mol |
| 結(jié)構(gòu)式 |  |
NETAMIFTIDE 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Water: 250 mg/mL (270.91 mM) |
Nemifitide diTFA (INN 00835 diTFA) 是一種合成的五肽抗抑郁藥，具有迅速起效的潛力。Nemifitide diTFA 是黑色素細(xì)胞抑制因子 (MIF) 的肽類似物。Nemifitide diTFA 可以透過血腦屏障。
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
| Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
| Dosage: | 0.3 mg/kg |
| Administration: | IP; daily; for 14 days |
| Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
| 2024/11/08 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |