DBCO-(PEG2-VAL-CIT-PAB)2
| 中文名稱 | DBCO-(PEG2-VAL-CIT-PAB)2 |
|---|---|
| 中文同義詞 | |
| 英文名稱 | DBCO-(PEG2-Val-Cit-PAB)2 |
| 英文同義詞 | DBCO-(PEG2-Val-Cit-PAB)2 |
| CAS號(hào) | |
| 分子式 | |
| 分子量 | 0 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |
DBCO-(PEG2-VAL-CIT-PAB)2 性質(zhì)
DBCO-(PEG2-Val-Cit-PAB)2 是一種可降解 (cleavable) 的含 4 個(gè)單元 PEG 的 ADC linker，可用于合成抗體偶聯(lián)藥物 (ADC)。DBCO-(PEG2-Val-Cit-PAB)2 也是一種基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
|
Cleavable
|
Alkyl/ether
|
PEGs
|
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.