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125941-87-9

125941-87-9

中文名稱125941-87-9
中文同義詞化合物SCH 23390 HYDROCHLORIDE;(R)-8-氯-3-甲基-5-苯基-2,3,4,5-四氫-1H-苯并[D]氮雜卓-7-醇鹽酸鹽;SCH 23390 鹽酸鹽
英文名稱R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
英文同義詞R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE;SCH 23390 HYDROCHLORIDE;R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride;SCH 23390(HCI);(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS號(hào)125941-87-9
分子式C17H18ClNOHCl
分子量324.24
EINECS號(hào)
相關(guān)類別Dopamine receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件125941-87-9.mol
結(jié)構(gòu)式125941-87-9 結(jié)構(gòu)式

125941-87-9 性質(zhì)

比旋光度+27~+31°(D/20℃)(c=0.5,DMF)
儲(chǔ)存條件protect from light
溶解度在水中的溶解度>5mg/mL
形態(tài)固體
顏色白色
旋光性 (optical activity)[α]/D +32.1°, c = 1 in DMF(lit.)
EPA化學(xué)物質(zhì)信息(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)

125941-87-9 用途與合成方法

SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390)是一種高效且選擇性強(qiáng)的 dopamine D1-like receptor 的拮抗劑,對(duì)于D1和D5多巴胺受體亞型的Ki值分別為0.2 nM和0.3 nM。SCH-23390 hydrochloride 是一種有效的 h5-HT2C receptors 的激動(dòng)劑,Ki值為9.3 nM。SCH-23390 hydrochloride 可直接抑制 G protein-coupled inwardly rectifying potassium (GIRK) channels,IC50值為268 nM。
TargetValue
D1 dopamine receptor
(Cell-free assay)
0.2 nM(Ki)
D5 dopamine receptor
(Cell-free assay)
0.3 nM(Ki)
h5-HT2C receptor
(Cell-free assay)
9.3 nM(Ki)
GIRK
(Cell-free assay)
268 nM

SCH-23390 (1?μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D 1 receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O 2 conditions.

安全信息

WGK Germany3

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-19545ASCH-23390 hydrochloride1 mg350元
2024/08/19HY-19545A125941-87-9
SCH-23390 hydrochloride
125941-87-95mg770元

125941-87-9 上下游產(chǎn)品信息

"125941-87-9"相關(guān)產(chǎn)品信息
SCH58261 NF-2 (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)對(duì)二氮己環(huán)-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺 6-氯間甲酚OR3-甲基-6-氯苯酚 2-(4-氯苯基)丙-1-胺鹽酸鹽 2-(3-氯苯基)乙胺 2-氯-4,5-二甲酚 4-氯苯乙胺
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