| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:PDGFRα kinase inhibitor 1
CAS:2209053-93-8
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PDGFRα kinase inhibitor 1
CAS:2209053-93-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
PDGFRα kinase inhibitor 1 manufacturers
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| | PDGFRα kinase inhibitor 1 Basic information |
| Product Name: | PDGFRα kinase inhibitor 1 | | Synonyms: | PDGFRα kinase inhibitor 1;3-Pyridinecarboxamide, N-[2-(dimethylamino)ethyl]-N-[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-;PDGFRα kinase inhibitor 1 | | CAS: | 2209053-93-8 | | MF: | C34H34N8O2 | | MW: | 586.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2209053-93-8.mol |  |
| | PDGFRα kinase inhibitor 1 Chemical Properties |
| density | 1.271±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 260 mg/mL (443.16 mM; Need ultrasonic) | | pka | 13.06±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | PDGFRα kinase inhibitor 1 Usage And Synthesis |
| Biological Activity | PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].
PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1]. | | References | [1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384. |
| | PDGFRα kinase inhibitor 1 Preparation Products And Raw materials |
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