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881179-02-8

881179-02-8

中文名稱881179-02-8
中文同義詞化合物 T11858;化合物 LITH-O-ASP
英文名稱Lith-O-Asp
英文同義詞Lith-O-Asp;Cholan-24-oic acid, 3-[(2S)-2-amino-3-carboxy-1-oxopropoxy]-, (3α,5β)-;LithOAsp,Lith O Asp
CAS號(hào)881179-02-8
分子式C28H45NO6
分子量491.67
EINECS號(hào)
相關(guān)類別
Mol文件881179-02-8.mol
結(jié)構(gòu)式881179-02-8 結(jié)構(gòu)式

881179-02-8 性質(zhì)

熔點(diǎn)208-209 °C
沸點(diǎn)635.0±45.0 °C(Predicted)
密度1.19±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C
溶解度二甲基亞砜:≥ 106 mg/mL(215.60 mM)
酸度系數(shù)(pKa)3.43±0.19(Predicted)
形態(tài)固體
顏色白色至米白色

881179-02-8 用途與合成方法

Lith-O-Asp 是唾液酸轉(zhuǎn)移酶 (ST) 的抑制劑,其 IC50 值在 12-37 μM 之間。

IC50: 12-37 μM (ST).

The results indicate that Lith-O-Asp shows no apparent growth inhibition effect toward different cancer cell lines at the tested doses of 10, 30, and 60 μM. By in vitro activity assay, it is revealed that the ability of Lith-O-Asp to inhibit the activities of ST3Gal I, ST3Gal III, and ST6GalI. The IC 50 values ranged from 12 to 37 μM. Flow cytometry shows a significant decrease in the expression of cell surface a-2,3- and a-2,6-sialylated antigens on The results indicates that Lith-O-Asp decreased the activity of both a-2,3- and a-2,6-sialyltransferases, and thus inhibit the transfer of sialic acids to the targeted glycoproteins.

A significant amount of secondary metastatic cancer cells are observed in lung tissues of DMSO control mice detected using IVIS in vivo imaging system after 26 days of fat pad inoculation. However, Lith-O-Asp–treated mice show fewer lung metastases. All DMSO-treated mice confirm secondary lung metastasis, but only 3 of 8 Lith-O-Asp-treated mice show lung metastasis. Average tumor nodules per mouse are 11±9 nodules in DMSO-treated group, and 2±4 nodules in Lith-O-Asp-treated group. Additionally, significantly stronger 4T1-Luc illumination signals are shown in control mice than in those injected with Lith-O-Asp-treated cancer cells on days 7 and 9.

安全信息

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-112415Lith-O-Asp1 mg2200元
2024/11/08HY-112415881179-02-8
Lith-O-Asp
881179-02-85mg5500元

881179-02-8 上下游產(chǎn)品信息

"881179-02-8"相關(guān)產(chǎn)品信息
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