- Fmoc-Val-Ala-PAB
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- $0.00 / 1g
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2024-03-29
- CAS:1394238-91-5
- Min. Order: 1g
- Purity: >95.00%
- Supply Ability: 1g
- Fmoc-Val-Ala-PAB-OH
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- $0.00 / 1KG
-
2022-10-14
- CAS:1394238-91-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
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| | Fmoc-Val-Ala-PAB-OH Basic information |
| Product Name: | Fmoc-Val-Ala-PAB-OH | | Synonyms: | CS-2746;Fmoc-Val-Ala-PAB-OH, 9-fluorenylmethyloxycarbonyl-valyl-alanyl-4-aminobenzylalcohol;L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-;Fmoc-Val-Ala-PAB-OH;Fmoc-Val-ala-PAB;(9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;1-Butanesulfonicacid,6-hydroxy-;Inhibitor,Antibody-drug conjugates linkers,ADC Linkers,Fmoc Val Ala PAB OH,inhibit,FmocValAlaPABOH | | CAS: | 1394238-91-5 | | MF: | C30H33N3O5 | | MW: | 515.6 | | EINECS: | | | Product Categories: | Linker;ADCs Linkers;ADCs;ADC LINKER;ADC-Linker | | Mol File: | 1394238-91-5.mol |  |
| | Fmoc-Val-Ala-PAB-OH Chemical Properties |
| Melting point | 218 °C(dec.) | | Boiling point | 811.1±65.0 °C(Predicted) | | density | 1.251±0.06 g/cm3(Predicted) | | solubility | DMSO : 33.33 mg/mL (64.64 mM; ultrasonic and warming and heat to 80°C) | | pka | 10.63±0.46(Predicted) | | form | powder to crystal | | color | White to Light yellow |
| | Fmoc-Val-Ala-PAB-OH Usage And Synthesis |
| Description | Fmoc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. | | Uses | Fmoc-Val-Ala-PAB is a building block used in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers. |
| | Fmoc-Val-Ala-PAB-OH Preparation Products And Raw materials |
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