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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >JAK inhibitors >Cerdulatinib HCl salt

Cerdulatinib HCl salt

Cerdulatinib HCl salt Suppliers list
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Products Intro: Product Name:Cerdulatinib HCl salt
CAS:1369761-01-2
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:Cerdulatinib HCl
CAS:1369761-01-2
Purity:>98% Package:10mg Remarks:BOC Sciences also provides custom synthesis services for Cerdulatinib HCl.
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Products Intro: Product Name:Cerdulatinib hydrochloride
CAS:1369761-01-2
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CAS:1369761-01-2
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Products Intro: Product Name:Cerdulatinib hydrochloride
CAS:1369761-01-2
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

Cerdulatinib HCl salt manufacturers

Cerdulatinib HCl salt Basic information
Product Name:Cerdulatinib HCl salt
Synonyms:Cerdulatinib HCl salt;4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1);Cerdulatinib (PRT062070, PRT2070);Cerdulatinib HCl;Cerdulatinib hydrochloride;Cerdulatinib HCl salt USP/EP/BP;PRT2070 hydrochloride;PRT062070 hydrochloride
CAS:1369761-01-2
MF:C20H28ClN7O3S
MW:481.99942
EINECS:
Product Categories:Inhibitors
Mol File:1369761-01-2.mol
Cerdulatinib HCl salt Structure
Cerdulatinib HCl salt Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)
form Solid
color Light brown to brown
Safety Information
MSDS Information
Cerdulatinib HCl salt Usage And Synthesis
Biological ActivityCerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.
in vitro

Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

in vivoIn a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.
target< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
(Cell-free assay)
TargetValue
TYK2
(Cell-free assay)
0.5 nM
MST1
(Cell-free assay)
4 nM
4 nM
MLK1
(Cell-free assay)
5 nM
Fms
(Cell-free assay)
5 nM
Cerdulatinib HCl salt Preparation Products And Raw materials
Tag:Cerdulatinib HCl salt(1369761-01-2) Related Product Information
Pyridine hydrochloride 2'-Deoxyuridine Aniline hydrochloride Trimethylamine hydrochloride Betaine hydrochloride Methylamine hydrochloride Saracatinib 5-Azacytidine BIRB 796 (Doramapimod) 1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one Afatinib

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