SCYLIORHININ II
| 中文名稱(chēng) | SCYLIORHININ II |
|---|---|
| 中文同義詞 | 選擇性的神經(jīng)激肽-3(NEUROKININ-3TACHYKININ)受體激動(dòng)劑 |
| 英文名稱(chēng) | scyliorhinin II |
| 英文同義詞 | PubChem ID: 101569057;L-Methioninamide, L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-seryl-L-lysyl-L-cysteinyl-L-prolyl-L-α-aspartylglycyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-valylglycyl-L-leucyl-, cyclic (7→13)-disulfide |
| CAS號(hào) | 112748-19-3 |
| 分子式 | C77H119N21O26S3 |
| 分子量 | 1851.09 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 112748-19-3.mol |
| 結(jié)構(gòu)式 |  |
SCYLIORHININ II 性質(zhì)
| 沸點(diǎn) | 2202.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 4.01±0.10(Predicted) |
Scyliorhinin II 是一種選擇性的神經(jīng)激肽-3 (neurokinin-3 tachykinin) 受體激動(dòng)劑，對(duì)大鼠腦皮層的 neurokinin-3 受體的 Ki 值為 2.5 nM。
Ki: 2.5 nM (Neurokinin-3 receptor)
Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a K i of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with K i (NK-1 receptor)/K i (NK-3 receptor) and K i (NK-2 receptor)/K i (NK-3 receptor) of 176 and 200.
Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED 50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice.