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| | 4-Iodo-2-(trifluoromethyl)pyridine Basic information |
| | 4-Iodo-2-(trifluoromethyl)pyridine Chemical Properties |
| Melting point | 24-26 °C | | Boiling point | 206.2±35.0 °C(Predicted) | | density | 1.974g/ml | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | liquid | | pka | -0.82±0.20(Predicted) | | color | Clear, colourless to pale yellow |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 4-Iodo-2-(trifluoromethyl)pyridine Usage And Synthesis |
| Uses | 4-Iodo-2-(trifluoromethyl)pyridine is used as a reagent in the synthesis of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors which exhibit in vivo brain reduction of β-amyloid peptides. | | Reactivity Profile | 4-Iodo-2-(trifluoromethyl)pyridine could be cleanly deprotonated by
LIDA in tetrahydrofuran at –75 °C[1]. Trapping of the organometallic intermediates with dry ice followed by neutralization gave the 4-iodo-2-(trifluoromethyl)pyridine-3-carboxylic acid (16, 31%). a: LIDA in THF at –75 °C for 2 h; b: (1.) Excess solid
carbon dioxide, (2.) Hydrochloric acid. | | References | [1] Schlosser M, et al. Further Metalations and Functionalizations of Chloro-, Bromo- and
Iodo(trifluoromethyl)pyridines. Synthesis, 2004; 10: 1619-1624. |
| | 4-Iodo-2-(trifluoromethyl)pyridine Preparation Products And Raw materials |
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