- m-PEG4-Boc
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- $0.00 / 100mg
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2024-10-24
- CAS:883554-11-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| m-PEG4-t-butyl ester Basic information |
Product Name: | m-PEG4-t-butyl ester | Synonyms: | m-PEG4-t-butyl ester;mPEG4-CH2CH2COOtBu;tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate/m-PEG4-t-butyl ester;m-PEG4-Boc;4,7,10,13-Tetraoxatetradecanoic acid, 1,1-dimethylethyl ester;mPEG3-CH2CH2COOtBu;tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate | CAS: | 883554-11-8 | MF: | C14H28O6 | MW: | 292.37 | EINECS: | | Product Categories: | | Mol File: | 883554-11-8.mol |  |
| m-PEG4-t-butyl ester Chemical Properties |
form | Liquid | color | Colorless to off-white |
| m-PEG4-t-butyl ester Usage And Synthesis |
Description | m-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | Uses | m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. | IC 50 | PEGs; Cleavable Linker | References | [1] Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1. [2] Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1. |
| m-PEG4-t-butyl ester Preparation Products And Raw materials |
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Tag:m-PEG4-t-butyl ester(883554-11-8)
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