化合物 T15506
中文名稱 | 化合物 T15506 |
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中文同義詞 | 化合物 T15506;化合物 HTS01037 |
英文名稱 | HTS 01037 |
英文同義詞 | HTS 01037;HTS 01037 (HTS01037;4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid;[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester |
CAS號 | 682741-29-3 |
分子式 | C14H11NO5S2 |
分子量 | 337.37 |
EINECS號 | |
相關(guān)類別 | |
Mol文件 | 682741-29-3.mol |
結(jié)構(gòu)式 | ![]() |
化合物 T15506 性質(zhì)
沸點(diǎn) | 621.2±55.0 °C(Predicted) |
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密度 | 1.493±0.06 g/cm3(Predicted) |
儲存條件 | RT |
溶解度 | 溶于 DMSO(高達(dá) 50 mg/ml) |
形態(tài) | 固體 |
酸度系數(shù)(pKa) | 3.39±0.10(Predicted) |
顏色 | 粘黃色 |
穩(wěn)定性 | 自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20°C 下保存長達(dá) 2 個(gè)月。 |
IC50: 0.67 μM (AFABP/aP2)
HTS01037 functions as a high affinity ligand of AFABP/aP2 with an apparent K i of 0.67 μM. HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells. Treatment of microglial cells with HTS01037 increases expression of Ucp2 and arginase in the presence or absence of palmitic acid. Moreover, cells exposed to HTS01037 exhibits attenuated expression of inducible nitric oxide synthase (iNOS) compared to palmitic acid alone indicating reduced NFκB signaling. Treatment of macrophages with HTS01037results in a marked decrease in both basal and fatty acid-stimulated LTC4 secretion but no change in 5-HETE production or 5-lipoxygenase expression.
安全信息
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
---|---|---|---|---|---|
2025/02/08 | HY-101503 | 化合物 T15506 HTS01037 | 682741-29-3 | 5mg | 770元 |
2025/02/08 | HY-101503 | 化合物 T15506 HTS01037 | 682741-29-3 | 10mM * 1mLin DMSO | 847元 |