2H4]-D,L-2-羥基戊二酸
| 中文名稱 | 2H4]-D,L-2-羥基戊二酸 |
|---|---|
| 中文同義詞 | |
| 英文名稱 | C02630 |
| 英文同義詞 | C02630;alpha-hydroxyglutarate;2,3-Dideoxypentaric Acid;a-Hydroxyglutaric Acid;DL-2-Hydroxyglutaric Acid;2-hydroxyglutarate;α-Hydroxyglutaric Acid |
| CAS號 | 2889-31-8 |
| 分子式 | C5H8O5 |
| 分子量 | 148.11 |
| EINECS號 | |
| 相關(guān)類別 | Aliphatics |
| Mol文件 | 2889-31-8.mol |
| 結(jié)構(gòu)式 | ![2H4]-D,L-2-羥基戊二酸 結(jié)構(gòu)式](CAS/20180808/GIF/2889-31-8.gif) |
2H4]-D,L-2-羥基戊二酸 性質(zhì)
| 熔點 | 98-100 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| 沸點 | 394.2±27.0 °C(Predicted) |
| 密度 | 1.508±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：30mg/mL； PBS（pH 7.2）：10 mg/mL |
| 形態(tài) | 液體 |
| 酸度系數(shù)(pKa) | 3.67±0.10(Predicted) |
| 顏色 | 無色至淺黃 |
α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羥基酸形式。α-Hydroxyglutaric acid 是多種 α-酮戊二酸依賴性雙加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羥化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的競爭性抑制劑。
Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.