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BW 245C

BW 245C

中文名稱BW 245C
中文同義詞化合物 T14842;化合物 BW 245C
英文名稱BW 245C
英文同義詞BW 245C;(4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID;3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-;4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-;3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid;4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-
CAS號72814-32-5
分子式C19H32N2O5
分子量368.47
EINECS號
相關(guān)類別
Mol文件72814-32-5.mol
結(jié)構(gòu)式BW 245C 結(jié)構(gòu)式

BW 245C 性質(zhì)

密度1.167±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度DMSO:30 mg/mL,可溶
形態(tài)固體
酸度系數(shù)(pKa)4.77±0.10(Predicted)
顏色米白色

BW 245C 用途與合成方法

BW 245C 是一種有效的前列腺素類DP受體prostanoid DP-receptor (DP1)激動劑,常用于中風(fēng)等疾病的研究。

DP/DP1 Receptor

BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity.

BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1 ?/? mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1 ?/? mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs.

安全信息

WGK Germany3

MSDS信息

提供商 語言
英文
更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-101987BW 245C
BW 245C
72814-32-51mg1400元
2025/02/08HY-101987BW 245C
BW 245C
72814-32-510 mM * 1 mLin DMSO2432元

BW 245C 上下游產(chǎn)品信息

"BW 245C"相關(guān)產(chǎn)品信息
1,3-二丁基脲 甲酰乙內(nèi)脲
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