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| | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Basic information |
| Product Name: | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole | | Synonyms: | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;5-[4'-METHYL (1,1'-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE;n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole;N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE;5-(4'-Methyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole;5-[4''-METHYL (1,1''-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE 98.5+%;N-TriphenylMethyl-5-[4'-Methylbiphenyl-2-yl]tetrazole-d4;5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole | | CAS: | 124750-53-4 | | MF: | C33H26N4 | | MW: | 478.59 | | EINECS: | | | Product Categories: | Biphenyl & Diphenyl ether;API intermediates;Hypertension | | Mol File: | 124750-53-4.mol |  |
| | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Chemical Properties |
| Melting point | 166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2)) | | Boiling point | 681.6±65.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly) | | form | Solid | | pka | 0.30±0.10(Predicted) | | color | Off-White | | CAS DataBase Reference | 124750-53-4(CAS DataBase Reference) |
| | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Usage And Synthesis |
| Chemical Properties | Off-white Solid | | Uses | An intermediate in the preparation of labelled Candesartan. | | Uses | 5-?(4''-?Methyl-?[1,?1''-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole is a reactant in the synthesis of anti-microbial agents. | | Synthesis | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.
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| | 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Preparation Products And Raw materials |
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