Β-AMINOARTEETHER
| 中文名稱 | Β-AMINOARTEETHER |
|---|---|
| 中文同義詞 | 化合物Β-AMINOARTEETHER |
| 英文名稱 | Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- |
| 英文同義詞 | Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-;β-Aminoarteether;SM934 free base |
| CAS號(hào) | 133162-24-0 |
| 分子式 | C17H29NO5 |
| 分子量 | 327.42 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 133162-24-0.mol |
| 結(jié)構(gòu)式 |  |
Β-AMINOARTEETHER 性質(zhì)
| 沸點(diǎn) | 421.0±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 8.46±0.10(Predicted) |
β-Aminoarteether (SM934 free base) 是一種具有口服活性的 Artemisinin 衍生物。β-Aminoarteether 可用于炎癥和自身免疫性疾病的研究，例如狼瘡疾病。
β-Aminoarteether (SM934;10 μM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation.
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice.
| Animal Model: | Female NZB/W F1 mice (Six and half months old) |
| Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg |
| Administration: | Oral administration; daliy; for 3 months |
| Result: | Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |