| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Package:1mg/RMB 560;5mg/RMB 1900;10mg/RMB 3200
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| Company Name: |
Shanghai Easy CDMO Co.,Ltd
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| Tel: |
021-61734564 |
| Email: |
August@easycdmo.com |
| Products Intro: |
Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:98% Package:5g；10g；20g；100g；100kg
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:95.00% Package:1mg;5mg;10mg
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2H-Cho-Arg (trifluoroacetate salt) manufacturers
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| | 2H-Cho-Arg (trifluoroacetate salt) Basic information |
| | 2H-Cho-Arg (trifluoroacetate salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| | 2H-Cho-Arg (trifluoroacetate salt) Usage And Synthesis |
| Description | 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.1 It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml). | | References | 1. Sheng, R., Wang, Z., Luo, T., et al. Skeleton-controlled pDNA delivery of renewable steroid-based cationic lipids, the endocytosis pathway analysis and intracellular localization Int. J. Mol. Sci. 19(2),(2018). |
| | 2H-Cho-Arg (trifluoroacetate salt) Preparation Products And Raw materials |
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