261766-73-8
| 中文名稱(chēng) | 261766-73-8 |
|---|---|
| 中文同義詞 | 化合物 T10169;化合物5-HT4 ANTAGONIST 1 |
| 英文名稱(chēng) | 5-HT4 antagonist 1 |
| 英文同義詞 | 5-HT4 antagonist 1;1,4-Benzodioxin-5-carboxamide, 2,3-dihydro-N-[[1-[3-[(4-methyl-1-piperazinyl)sulfonyl]propyl]-4-piperidinyl]methyl]-;inhibit,5-HT4 antagonist 1,5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT Receptor,5 HT4 antagonist 1,5-HT-4 antagonist 1,Inhibitor,5HT4 antagonist 1 |
| CAS號(hào) | 261766-73-8 |
| 分子式 | C23H36N4O5S |
| 分子量 | 480.62 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 261766-73-8.mol |
| 結(jié)構(gòu)式 |  |
261766-73-8 性質(zhì)
| 密度 | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.39±0.20(Predicted) |
| 顏色 | 淺棕色至棕色 |
5-HT4 antagonist 1 是一個(gè) 5-HT4 受體拮抗劑， 其 pKi 值為 9.6。
|
5-HT 4 Receptor 9.6 (pKi) |
5-HT4 antagonist 1 (compound 6b) is a 5-HT 4 receptor antagonist with a pK i of 9.6.
5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t 1/2 in other species, including the mouse (t 1/2 7 h), rat (t 1/2 12 h) and mini-pig (t 1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t 1/2 of >100 h.