BI-409306 manufacturers
- Osoresnontrine
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- $74.00 / 5mg
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2025-05-01
- CAS:1189767-28-9
- Min. Order:
- Purity: 99.93%
- Supply Ability: 10g
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| | BI-409306 Basic information |
| Product Name: | BI-409306 | | Synonyms: | BI-409306;BI 409306
(BI-409306;CS-2883;BI 409306;BI-409306;BI409306;6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-;6-(Pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one;Osoresnontrine | | CAS: | 1189767-28-9 | | MF: | C16H17N5O2 | | MW: | 311.34 | | EINECS: | 810-297-6 | | Product Categories: | | | Mol File: | 1189767-28-9.mol |  |
| | BI-409306 Chemical Properties |
| Boiling point | 559.8±60.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:62.0(Max Conc. mg/mL);199.14(Max Conc. mM) | | form | A crystalline solid | | pka | 3.94±0.12(Predicted) | | color | White to off-white |
| | BI-409306 Usage And Synthesis |
| Uses | Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders. | | IC 50 | PDE9A: 52 nM (IC50); PDE1C: 1 μM (IC50); PDE1A: 1.4 μM (IC50) | | References | [1] Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research. |
| | BI-409306 Preparation Products And Raw materials |
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