METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
生物活性靶點(diǎn)體外研究體內(nèi)研究 用途與合成方法 MSDS METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE價(jià)格(試劑級) 上下游產(chǎn)品信息
| 中文名稱 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE |
|---|---|
| 中文同義詞 | 化合物R-10015;2-(1-(5-氯-7H-吡咯并[2,3-D]嘧啶-4-基)哌啶-4-基)-1H-苯并[D]咪唑-6-羧酸甲酯;化合物R-10015,10 MM DMSO 溶液 |
| 英文名稱 | 1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester |
| 英文同義詞 | 1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate;methyl 2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;R-10015,inhibit,R10015,Inhibitor,LIMKs,Reverse Transcriptase,LIM Kinase (LIMK),R 10015;R-10015, 10 mM in DMSO |
| CAS號 | 2097938-51-5 |
| 分子式 | C20H19ClN6O2 |
| 分子量 | 410.86 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 2097938-51-5.mol |
| 結(jié)構(gòu)式 | ![METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 結(jié)構(gòu)式](CAS/20200331/GIF/2097938-51-5.gif) |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 性質(zhì)
| 密度 | 1.465±0.06 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | DMSO：62.5 mg/mL（152.12 mM；需要超聲波） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 10.68±0.10(Predicted) |
| 顏色 | 米白色至粉紅色 |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 用途與合成方法
R-10015 是一種有效的、具有選擇性的 LIM domain kinase (LIMK) 抑制劑，對于人LIMK1的IC50值為38 nM。R-10015 會結(jié)合到 ATP-binding pocket 上，并充當(dāng)HIV感染的廣譜抗病毒化合物。
| Target | Value |
|
hLIMK1
(Cell-free assay) | 38 nM |
R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.
R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .
Western Blot Analysis
| Cell Line: | CEM-SS T cells |
| Concentration: | 100 μM |
| Incubation Time: | 0 hour,0.5 hour,1 hour,2 hours,4 hours |
| Result: | Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. |
R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.
| Animal Model: | 6-8 weeks female C3H/HeN mice |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Displayed none indication of toxicity. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/05 | S6837 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015 | 2097938-51-5 | 2mg | 1870.64元 |
| 2025/02/05 | S6837 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015 | 2097938-51-5 | 5mg | 3700.86元 |