133406-29-8
| 中文名稱(chēng) | 133406-29-8 |
|---|---|
| 中文同義詞 | 6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;化合物ST034307;ST 034307,腺苷酸環(huán)化酶1(AC1)抑制劑;化合物ST034307,10 MM DMSO 溶液 |
| 英文名稱(chēng) | ST034307 |
| 英文同義詞 | ST034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;ST034307;ST-034307;ST 034307;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;ST034307 >=98% (HPLC);Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase;ST034307, 10 mM in DMSO |
| CAS號(hào) | 133406-29-8 |
| 分子式 | C10H4Cl4O2 |
| 分子量 | 297.95 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 133406-29-8.mol |
| 結(jié)構(gòu)式 |  |
133406-29-8 性質(zhì)
| 沸點(diǎn) | 329.1±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.674±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 可溶于 DMSO（高達(dá) 30 mg/ml）或乙醇（高達(dá) 6 mg/ml） |
| 形態(tài) | 固體 |
| 顏色 | 粘黃色 |
| 穩(wěn)定性 | 自購(gòu)買(mǎi)之日起，穩(wěn)定期為 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存長(zhǎng)達(dá) 3 個(gè)月。 |
IC50: 2.3 μM (AC1)
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca 2+ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-101279 | 133406-29-8 ST034307 | 133406-29-8 | 5mg | 770元 |
| 2025/02/08 | HY-101279 | 133406-29-8 ST034307 | 133406-29-8 | 10mM * 1mLin DMSO | 847元 |