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GSK8814

GSK8814 Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:GSK8814
CAS:1997369-78-4
Purity:99% Package:25KG;5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:GSK8814
CAS:1997369-78-4
Purity:98.00% Package:100mg;|25mg;10260USD|50mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:GSK8814
CAS:1997369-78-4
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:GSK8814
CAS:1997369-78-4
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:GSK8814
CAS:1997369-78-4
Purity:>=99.0% Package:$460.9/5mg;$780.9/10mg;Bulk package Remarks:99.0%

GSK8814 manufacturers

  • GSK8814
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  • $0.00 / 100mg
  • 2024-10-28
  • CAS:1997369-78-4
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  • Supply Ability: 10g
GSK8814 Basic information
Product Name:GSK8814
Synonyms:GSK8814;1,7-Naphthyridin-2(1H)-one, 8-[[(3R,4R,5S)-3-[(4,4-difluorocyclohexyl)methoxy]-5-methoxy-4-piperidinyl]amino]-3-methyl-5-(5-methyl-3-pyridinyl)-;GSK8814,GSK-8814
CAS:1997369-78-4
MF:C28H35F2N5O3
MW:527.61
EINECS:
Product Categories:
Mol File:1997369-78-4.mol
GSK8814 Structure
GSK8814 Chemical Properties
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
GSK8814 Usage And Synthesis
Biological ActivityGSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].
References[1]. Bamborough P, et al. A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. [2]. Bamborough P, et al. Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J Med Chem. 2018 Sep 27;61(18):8321-8336.
GSK8814 Preparation Products And Raw materials
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