CLOFOCTOL manufacturers
- Clofoctol
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- $74.00 / 100mg
-
2024-10-28
- CAS:37693-01-9
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
- Clofoctol
-
- $74.00 / 100mg
-
2024-10-25
- CAS:37693-01-9
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
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| | CLOFOCTOL Basic information |
| Product Name: | CLOFOCTOL | | Synonyms: | CLOFOCTOL;2-[2,4-DICHLOROBENZYL]-4-[1,1,3,3-TETRAMETHYLBUTYL]PHENOL;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)-pheno;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)phenol;α-[2,4-Dichlorophenyl]-4-[1,1,3,3-tetramethylbutyl]-o-cresol;Gramplus;Octofene;2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol | | CAS: | 37693-01-9 | | MF: | C21H26Cl2O | | MW: | 365.34 | | EINECS: | 253-632-6 | | Product Categories: | OCTOPHENE | | Mol File: | 37693-01-9.mol |  |
| | CLOFOCTOL Chemical Properties |
| Melting point | 78° | | Boiling point | 447.7±40.0 °C(Predicted) | | density | 1.127±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:100.0(Max Conc. mg/mL);273.72(Max Conc. mM) | | form | Solid | | pka | 10.09±0.45(Predicted) | | color | White to off-white |
| WGK Germany | 2 | | RTECS | SL0533000 | | Toxicity | LD50 orally in male rats: >4 g/kg (Debat) |
| | CLOFOCTOL Usage And Synthesis |
| Originator | Octofene,Debat,France,1978 | | Uses | antibacterial | | Uses | Clofoctol is a bacteriostatic antibiotic used against gram-positive bacteria. | | Definition | ChEBI: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane. | | Manufacturing Process | The following were introduced into a 1 liter flask provided with a reflux
condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75
mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc
chloride, and 750 ml of anhydrous chloroform.
The mixture was heated to reflux for 24 hours. The chloroformic reaction
mixture was washed with water, and then dried over anhydrous sodium
sulfate. The chloroform was evaporated off and the oil obtained was
fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at
140°C to 160°C, being the desired product indicated above, was collected and
crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in
petroleum ether). | | Therapeutic Function | Antiinfective, Bacteriostatic |
| | CLOFOCTOL Preparation Products And Raw materials |
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