| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Diclofenac-d4
CAS:153466-65-0
Package:10Mg,1Mg
|
- Diclofenac-d4
-
- $0.00 / 5mg
-
2024-10-28
- CAS:153466-65-0
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | DICLOFENAC-D4 Basic information |
| Product Name: | DICLOFENAC-D4 | | Synonyms: | Diclofenac-D4 (Major);DICLOFENAC-D4;DICLOFENAC-D4 (PHENYL-D4);2-((2,6-Dichlorophenyl)aminobenzeneacetic Acid-d4,;2-[2,3,4,5-tetradeuterio-6-(2,6-dichloroanilino)phenyl]acetic acid;D4-Diclofenac;[2H4]-Diclofenac;Diclofenac D4Q: What is
Diclofenac D4 Q: What is the CAS Number of
Diclofenac D4 Q: What is the storage condition of
Diclofenac D4 Q: What are the applications of
Diclofenac D4 | | CAS: | 153466-65-0 | | MF: | C14H11Cl2NO2 | | MW: | 296.15 | | EINECS: | | | Product Categories: | Pharmaceuticals;Metabolites & Impurities;Intermediates & Fine Chemicals | | Mol File: | 153466-65-0.mol |  |
| | DICLOFENAC-D4 Chemical Properties |
| Melting point | 157-159°C | | storage temp. | -20°C Freezer | | solubility | DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml | | form | A solid | | color | White to off-white | | Water Solubility | Water: 50 mg/ml | | CAS DataBase Reference | 153466-65-0 |
| | DICLOFENAC-D4 Usage And Synthesis |
| Description | Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. | | Chemical Properties | Off-White Crystalline Solid | | Uses | Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2 | | Uses | Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. | | Uses | Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. |
| | DICLOFENAC-D4 Preparation Products And Raw materials |
|