- HOE 140
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- $50.00 / 10g
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2025-01-19
- CAS:130308-48-4
- Min. Order: 10g
- Purity: 98%
- Supply Ability: 2000kg
- Icatibant (HOE 140)
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- $0.00 / 1BOX
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2025-01-18
- CAS:130308-48-4
- Min. Order: 1BOX
- Purity: 99%
- Supply Ability: 20T
- Icatibant
-
- $0.00 / 1box
-
2025-01-18
- CAS:130308-48-4
- Min. Order: 1box
- Purity: 99.99%
- Supply Ability: 1000
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| | HOE 140 Basic information |
| Product Name: | HOE 140 | | Synonyms: | RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R;H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;Icatibant;D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin;D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Thi-L-Ser-D-Tic-L-Oic-L-Arg-OH;H0E-140;D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-3-(2-Thienyl)-L-Ala-L-Ser-D-Tic-[(3aS,7aS)-L-Oic-]-OH | | CAS: | 130308-48-4 | | MF: | C59H89N19O13S | | MW: | 1304.52 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 130308-48-4.mol |  |
| | HOE 140 Chemical Properties |
| density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM) | | form | powder | | pka | 3.60±0.21(Predicted) | | color | white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH | | InChIKey | QASONHYHOCRAHL-DOMVFXHKSA-N | | CAS DataBase Reference | 130308-48-4 |
| | HOE 140 Usage And Synthesis |
| Description | Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].
| | Uses | Antagonist (bradykinin). | | Definition | ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut
attacks of hereditary angioedema in adult patients. | | Brand name | Metastat (CollaGenex). | | Biological Activity |
Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20 nmol kg?1, inhibition still amounted to 60%, whereas the effect of 200 nmol kg?1 of d-Arg—[Hyp2, Thi5,8, d-Phe7]BK was not significant. In receptor binding studies in guinea-pig ileum preparations, Hoe 140 showed an IC50 of 1.07 × 10?9mol l?1 and a KI value of 7.98 × 10?10 mol l?1.
| | storage | Store at -20°C | | References |
[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.
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| | HOE 140 Preparation Products And Raw materials |
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