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CC-115 (hydrochloride)

CC-115 (hydrochloride) Suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:CC-115 hydrochloride
CAS:1300118-55-1
Purity:86899% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:CC-115 HYDROCHLORIDE
CAS:1300118-55-1
Purity:98% Package:5mg Remarks:V4345
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:CC-115 hydrochloride
CAS:1300118-55-1
Purity:98% Package:$90.9/5mg;$150.9/10mg;$520.9/50mg;Bulk package Remarks:98%
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:CC-115 hydrochloride
CAS:1300118-55-1
Package:500mg;1657USD
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:CC-115 hydrochloride
CAS:1300118-55-1
Purity:0.97 Package:mgs,gs,kgs Remarks:A920104

CC-115 (hydrochloride) manufacturers

  • CC-115 hydrochloride
  • CC-115 hydrochloride pictures
  • $1657.00 / 500mg
  • 2024-10-24
  • CAS:1300118-55-1
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
CC-115 (hydrochloride) Basic information
Product Name:CC-115 (hydrochloride)
Synonyms:CC-115 (hydrochloride);CC-115 HCl
CAS:1300118-55-1
MF:C16H17ClN8O
MW:372.82
EINECS:
Product Categories:
Mol File:1300118-55-1.mol
CC-115 (hydrochloride) Structure
CC-115 (hydrochloride) Chemical Properties
storage temp. Store at -20°C
solubility DMSO : ≥ 30 mg/mL (80.47 mM)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
CC-115 (hydrochloride) Usage And Synthesis
Description

CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. In a kinase selectivity assessment against a panel of 250 protein kinases at 3 μM, only one kinase other than mTOR kinase is identified with more than 50% inhibition (cFMS 57%, IC50=2.0 μM). Of the PI3K related kinases (PIKKs) tested, CC-115 proves to be equipotent against DNA PK (IC50=15 nM) and demonstrates 40 to >1000 fold selectivity against the remaining PIKKs tested; PI3K-alpha (IC50=0.85 μM), ATR (50% inhibition at 30 μM) and ATM (IC50>30 μM). The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG (human ether-a-go-go-related gene) ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3, IC50=0.63 μM)[1].

CC-115 hydrochloride shows good in vivo PK profiles across multiple species with 53%, 76% and ~100% oral bioavailability in mouse, rat and dog, respectively. CC-115 is tested at lower doses of 0.25, 0.5 and 1 mg/kg bid or 1 mg/kg qd, with observed corresponding tumor volume reductions of 46%, 57%, 66% and 57% respectively. CC-115 sustains inhibition though 24 hours. At the 1 mg/kg dose CC-115 shows significant inhibition at 1 and 3 hours, CC-115 demonstrating inhibition through 10 hours. CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules[1].

References

[1]. Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.

CC-115 (hydrochloride) Preparation Products And Raw materials
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