4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide manufacturers
- B355252
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- $32.00 / 1mg
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2024-11-12
- CAS:1261576-81-1
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
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| | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Basic information |
| Product Name: | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide | | Synonyms: | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide;B355252;2-Thiophenesulfonamide, 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-;B355252 >=98% (HPLC);4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide;neurite outgrowth,ischemic neurons,HT22,B355252,glutamate,Inhibitor,Apoptosis,DNA damage,inhibit,B 355252,NGF,LDH level,ROS production,Parkinson disease,phenoxy thiophene sulfonamide,B-355252 | | CAS: | 1261576-81-1 | | MF: | C25H24ClN3O3S2 | | MW: | 514.06 | | EINECS: | | | Product Categories: | | | Mol File: | 1261576-81-1.mol |  |
| | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Chemical Properties |
| Melting point | 142-144 °C | | Boiling point | 718.4±70.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | pka | 10.16±0.50(Predicted) | | color | white to beige |
| | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Usage And Synthesis |
| Description | B355252 is a neuroprotective agent. It potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM). B355252 inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner and inhibits glutamate-induced decreases in GSH levels and increases in Bax levels, intracellular accumulation of calcium, and production of reactive oxygen species (ROS) in HT-22 cells when used at a concentration of 8 μM. It also inhibits decreases in cell viability, increases in ROS production, and mitochondrial membrane depolarization induced by 6-hydroxydopamine (6-OHDA; ) in HT-22 cells, an in vitro model of Parkinson’s disease. |
| | 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Preparation Products And Raw materials |
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