NSC 366140 無(wú)結(jié)構(gòu)圖
| 中文名稱 | NSC 366140 無(wú)結(jié)構(gòu)圖 |
|---|---|
| 中文同義詞 | NSC 366140 無(wú)結(jié)構(gòu)圖;化合物 T28475;化合物PYRAZOLOACRIDINE |
| 英文名稱 | NSC 366140 |
| 英文同義詞 | Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-;(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE;NSC 366140;2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine;9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine;Pyrazoloacridine;1,2,6,10b-Tetrahydro-5-nitro-9-methoxy-2-[3-(dimethylamino)propyl]pyrazolo[3,4,5-kl]acridine;Brn 4211902 |
| CAS號(hào) | 99009-20-8 |
| 分子式 | C19H21N5O3 |
| 分子量 | 367.4 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 99009-20-8.mol |
| 結(jié)構(gòu)式 |  |
NSC 366140 無(wú)結(jié)構(gòu)圖 性質(zhì)
| 沸點(diǎn) | 584.3±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 酸度系數(shù)(pKa) | 9.35±0.28(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺棕色至橙色 |
Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓?fù)洚悩?gòu)酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 對(duì) K562 髓系白血病細(xì)胞中的 IC50 值為 1.25 μM (24 h)。
Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC
50
values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.
Pyrazoloacridine (NSC 366140) induces
apoptosis
in P53-deficient Hep 3B human hepatoma cells.
Cell Cytotoxicity Assay
| Cell Line: | K562 Myeloid Leukemia Cells. |
| Concentration: | 0-500 μM. |
| Incubation Time: | 1 h or 24 h. |
| Result: | When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-108969 | NSC 366140 無(wú)結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 5mg | 900元 |
| 2024/11/08 | HY-108969 | NSC 366140 無(wú)結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 10 mg | 1450元 |
上游原料