2,4-Dichloro-5-fluorobenzoyl chloride synthesis
- Product Name:2,4-Dichloro-5-fluorobenzoyl chloride
- CAS Number:86393-34-2
- Molecular formula:C7H2Cl3FO
- Molecular Weight:227.45
86522-89-6
204 suppliers
$6.00/1g
86393-34-2
180 suppliers
$7.00/5g
Yield:86393-34-2 99.1%
Reaction Conditions:
with bis(trichloromethyl) carbonate in toluene at 110;Industrial scale;Green chemistry;
Steps:
5 Preparation of 2,4-dichloro-5-fluorobenzoyl chloride
the second tube reactor: single tube, length 10m, pipe diameter 5mm; step 2 tube acylation reaction: to the storage device E into 2,4-dichloro-5-fluorobenzoic acid 2.00Kg, then add 2.00Kg of toluene, stir to dissolve the standby; and then to the receiver F into 0.90Kg of bis(trichloromethyl)carbonate and then add 1.00Kg of toluene, stirring dissolved in reserve.The valves of the accumulators E and F were opened and the molar flow ratio was controlled at a ratio of 1: 1.2 from the metering pump into the tubular reaction system. The tube reactor temperature was controlled to 110 ° C and the tube reactor was connected to the collector G, Collector G is distilled at atmospheric pressure, the solvent toluene and excess bis (trichloromethyl) carbonate are distilled off and then condensed back to the bis (trichloromethyl) carbonate toluene recovery device H, Collector G gives 2,4 -dichloro-5-fluorobenzoyl chloride. Distilled to collect 35mmHg, 143 ~ 144 ° C to obtain the final product 2,4-dichloro-5-fluorobenzoyl chloride 2.15Kg, the total yield of 99.1%.
References:
CN106966894,2017,A Location in patent:Paragraph 0033-0035
124-38-9
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1435-48-9
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86393-34-2
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$7.00/5g
704-10-9
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86393-34-2
180 suppliers
$7.00/5g
1435-48-9
364 suppliers
$6.00/5g
86393-34-2
180 suppliers
$7.00/5g