| | 896466-04-9 Basic information More.. |
| Product Name: | AT9283 | | Synonyms: | 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283;AT9283, >=98%;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;CS-48;AT-9283; AT 9283;J-504568 | | CAS: | 896466-04-9 | | MF: | C19H23N7O2 | | MW: | 381.43 | | EINECS: | | | Mol File: | 896466-04-9.mol |  |
Use
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]
- AT9283
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- US $39.00-96.00 / mg
- 2024-11-19
- CAS:896466-04-9
- Min. Order:
- Purity: 99.98%
- Supply Ability: 10g
- AT9283
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- US $2.00 / kg
- 2019-07-06
- CAS:896466-04-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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896466-04-9
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