| | 53984-36-4 Basic information More.. |
| Product Name: | 3-CHLORO-5-HYDROXY-BENZOIC ACID | | Synonyms: | 3-CHLORO-5-HYDROXY-BENZOIC ACID;5-(hydroxy)-3-chlorobenzoic acid;5-Chloro-m-salicylic Acid;3-chloro-5-hydroxy BA;Benzoic acid, 3-chloro-5-hydroxy-;GPR81 Agonist, 3Cl-5OH-BA;GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem;3-chloro-5-hydroxybenzoic Acid, 10 mM in DMSO | | CAS: | 53984-36-4 | | MF: | C7H5ClO3 | | MW: | 172.57 | | EINECS: | | | Mol File: | 53984-36-4.mol |  |
Use
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
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- US $3.00-0.20 / KG
- 2024-03-26
- CAS:53984-36-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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53984-36-4
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