モリブレシブ
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- ￥29800 - ￥96000
- 化學(xué)名: モリブレシブ
- 英語(yǔ)名: GSK 525762A
- 別名:モリブレシブ;(4S)-4,10b-ジヒドロ-1-メチル-6-(4-クロロフェニル)-8-メトキシ-2,3,5,10b-テトラアザベンゾ[e]アズレン-4-アセトアミド;2-[(7S)-9-(4-クロロフェニル)-12-メトキシ-3-メチル-2,4,5,8-テトラアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,8,10,12-ヘキサエン-7-イル]アセトアミド
- CAS番號(hào): 1260907-17-2
- 分子式: C22H22ClN5O2
- 分子量: 423.9
- EINECS:
- MDL Number:MFCD30207861
2物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1272
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明I-BET762 ≥98% (HPLC)
- 包裝単位5mg
- 価格￥29800
- 更新しました2024-03-01
- 購(gòu)入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1272
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明I-BET762 ≥98% (HPLC)
- 包裝単位25mg
- 価格￥96000
- 更新しました2024-03-01
- 購(gòu)入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML1272 | ≥98% (HPLC) I-BET762 ≥98% (HPLC) |
5mg | ￥29800 | 2024-03-01 | 購(gòu)入 |
| Sigma-Aldrich Japan | SML1272 | ≥98% (HPLC) I-BET762 ≥98% (HPLC) |
25mg | ￥96000 | 2024-03-01 | 購(gòu)入 |
プロパティ
融點(diǎn) :>132°C (dec.)
比重(密度) :1.35
貯蔵溫度 :2-8°C
溶解性 :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
酸解離定數(shù)(Pka) :15.71±0.46(Predicted)
外見 :powder
色 :white to beige
光學(xué)活性 (optical activity) :[α]/D +80 to +90°, c = 0.3 in methanol
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
比重(密度) :1.35
貯蔵溫度 :2-8°C
溶解性 :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
酸解離定數(shù)(Pka) :15.71±0.46(Predicted)
外見 :powder
色 :white to beige
光學(xué)活性 (optical activity) :[α]/D +80 to +90°, c = 0.3 in methanol
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
安全情報(bào)
| 絵表示(GHS): |
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| 注意喚起語(yǔ): | Warning | |||||||||||||||||||||||||||||||||||
| 危険有害性情報(bào): |
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説明
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM). It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages. Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.関連商品価格
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