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2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン

2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン price.
2物価
ブランド
  • 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
  • 5mg
  • 25mg
  • 生産者富士フイルム和光純薬株式會(huì)社(wako)
  • 製品番號(hào)SML1655
  • 製品説明BI-9564 ≥97% (HPLC)
  • 英語製品説明 ≥97% (HPLC)
  • 包裝単位25mg
  • 価格￥114000
  • 更新しました2024-03-01
  • 購入
  • 生産者富士フイルム和光純薬株式會(huì)社(wako)
  • 製品番號(hào)SML1655
  • 製品説明BI-9564 ≥97% (HPLC)
  • 英語製品説明 ≥97% (HPLC)
  • 包裝単位5mg
  • 価格￥28500
  • 更新しました2024-03-01
  • 購入
生産者 製品番號(hào) 製品説明 包裝単位 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會(huì)社(wako) SML1655 BI-9564 ≥97% (HPLC)
≥97% (HPLC)		 25mg ￥114000 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) SML1655 BI-9564 ≥97% (HPLC)
≥97% (HPLC)		 5mg ￥28500 2024-03-01 購入

プロパティ

貯蔵溫度  :Store at -20°C
溶解性 :≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
外見  :crystalline solid
色 :White to off-white

安全情報(bào)

絵表示(GHS): GHS hazard pictograms
注意喚起語: Danger
危険有害性情報(bào):
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
注意書き:

説明

BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. It does not bind to other bromodomain-containing BET family members (IC50s >100 μM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in in vitro ITC assays (Kd = 258 nM), but not in cell-based assays at concentrations up to 1 μM. BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both in vitro (EC50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day). See the Structural Genomics Consortium (SGC) website for more information.