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ChemicalBook >> CAS DataBase List >> Tenofovir

Tenofovir

Tenofovir price.
  • $5 - $1200
  • Product name: Tenofovir
  • CAS: 147127-20-6
  • MF: C9H14N5O4P
  • MW: 287.21
  • EINECS:604-571-2
  • MDL Number:MFCD07357269
  • Synonyms:D,L-TENOFOVIR;TENOFOVIR;1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid;Tenofovir disoproxil fumarate and intermediates;(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA)
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  • ManufacturerAK Scientific
  • Product numberJ40079
  • Product descriptionTenofovir
  • Packaging10mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0568AB
  • Product descriptionTenofovir
  • Packaging100g
  • Price$307
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging500g
  • Price$375
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging100g
  • Price$92
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging25g
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging10g
  • Price$12
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging5g
  • Price$7
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA193687
  • Product descriptionTenofovir 95%
  • Packaging1g
  • Price$5
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5275
  • Product descriptionTenofovir
  • Packaging25mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5275
  • Product descriptionTenofovir
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA5275
  • Product descriptionTenofovir
  • Packaging100mg
  • Price$150
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS022560
  • Product descriptionTenofovir 95%
  • Packaging50mg
  • Price$5
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS022560
  • Product descriptionTenofovir 95%
  • Packaging100mg
  • Price$7
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS022560
  • Product descriptionTenofovir 95%
  • Packaging1g
  • Price$11
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS022560
  • Product descriptionTenofovir 95%
  • Packaging5g
  • Price$17
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60298
  • Product descriptionTenofovir
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J40079 Tenofovir 10mg $98 2021-12-16 Buy
AK Scientific 0568AB Tenofovir 100g $307 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 500g $375 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 100g $92 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 25g $25 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 10g $12 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 5g $7 2021-12-16 Buy
Ambeed A193687 Tenofovir 95% 1g $5 2021-12-16 Buy
ApexBio Technology A5275 Tenofovir 25mg $50 2021-12-16 Buy
ApexBio Technology A5275 Tenofovir 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A5275 Tenofovir 100mg $150 2021-12-16 Buy
Arctom AS022560 Tenofovir 95% 50mg $5 2021-12-16 Buy
Arctom AS022560 Tenofovir 95% 100mg $7 2021-12-16 Buy
Arctom AS022560 Tenofovir 95% 1g $11 2021-12-16 Buy
Arctom AS022560 Tenofovir 95% 5g $17 2021-12-16 Buy
Arctom CFN60298 Tenofovir 20mg $30 2021-12-16 Buy

Properties

Melting point :276-280°C
alpha :D +21° (c = 1 in 0.1M HCl)
Boiling point :616.1±65.0 °C(Predicted)
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated)
pka :2.36±0.10(Predicted)
form :powder
color :white to beige
optical activity :[α]/D -20 to -26°, c = 0.5 in 1 M HCl
Water Solubility :13.4 mg/mL (25 ºC)
Merck :14,9146
InChI :InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChIKey :SGOIRFVFHAKUTI-ZCFIWIBFSA-N
SMILES :P(CO[C@H](C)CN1C2C(N=C1)=C(N)N=CN=2)(=O)(O)O
CAS DataBase Reference :147127-20-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tenofovir is an analog of adenosine monophosphate that has antiviral activity. It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ. For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil fumarate, which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.

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