Roscovitine
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- $22 - $2245.7
- Product name: Roscovitine
- CAS: 186692-46-6
- MF: C19H26N6O
- MW: 354.45
- EINECS:
- MDL Number:MFCD02266401
- Synonyms:2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine;(2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol;2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE;ROSCOVITINE;(R)-ROSCOVITINE;(R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
53 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Labseeker
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 500μg
- 1mg
- 2mg
- 20mg
- 50
- 500mg
- 200mg
- 10
- 10mM(in 1mL DMSO)
- 2.5MG
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0006-M005
- Product description(R)-Roscovitine ≥98%(NMR)
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0006-M050
- Product description(R)-Roscovitine ≥98%(NMR)
- Packaging50mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7381
- Product descriptionRoscovitine
- Packaging50mg
- Price$224
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging5mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging10mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging50mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging100mg
- Price$207
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging250mg
- Price$424
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA300507
- Product descriptionRoscovitine 98+%
- Packaging1g
- Price$1027
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000355
- Product descriptionRoscovitine 95.00%
- Packaging2.5MG
- Price$704
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000355
- Product descriptionRoscovitine 95.00%
- Packaging25MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1723
- Product descriptionRoscovitine(Seliciclib,CYC202)
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1723
- Product descriptionRoscovitine(Seliciclib,CYC202)
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1723
- Product descriptionRoscovitine(Seliciclib,CYC202)
- Packaging10mM(in 1mL DMSO)
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1723
- Product descriptionRoscovitine(Seliciclib,CYC202)
- Packaging25mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1723
- Product descriptionRoscovitine(Seliciclib,CYC202)
- Packaging100mg
- Price$200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0006-M005 | (R)-Roscovitine ≥98%(NMR) | 5mg | $90 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0006-M050 | (R)-Roscovitine ≥98%(NMR) | 50mg | $270 | 2021-12-16 | Buy |
| AK Scientific | X7381 | Roscovitine | 50mg | $224 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 5mg | $29 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 10mg | $49 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 50mg | $122 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 100mg | $207 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 250mg | $424 | 2021-12-16 | Buy |
| Ambeed | A300507 | Roscovitine 98+% | 1g | $1027 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000355 | Roscovitine 95.00% | 2.5MG | $704 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000355 | Roscovitine 95.00% | 25MG | $1871.1 | 2021-12-16 | Buy |
| ApexBio Technology | A1723 | Roscovitine(Seliciclib,CYC202) | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A1723 | Roscovitine(Seliciclib,CYC202) | 10mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A1723 | Roscovitine(Seliciclib,CYC202) | 10mM(in 1mL DMSO) | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A1723 | Roscovitine(Seliciclib,CYC202) | 25mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A1723 | Roscovitine(Seliciclib,CYC202) | 100mg | $200 | 2021-12-16 | Buy |
Properties
Melting point :106～107℃
Boiling point :577.5±60.0 °C(Predicted)
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form :White to off-white solid
pka :14.56±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference :186692-46-6(CAS DataBase Reference)
Boiling point :577.5±60.0 °C(Predicted)
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form :White to off-white solid
pka :14.56±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference :186692-46-6(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases which suppresses the proliferation of mammalian cell lines. Selective for Cdk1/cyclin B kinase (IC50=450nM), Cdk2 (IC50=700nM) and Cdk5/p35 (IC50=160nM). Roscovitine is more potent than olomoucine (sc-201526). It inhibits M phase promoting factor kinase activity and affects calcium channel gating. Roscovitine reversibly inhibits the transition from prophase to metaphase at micromolar concentrations in starfish oocytes and sea urchin embryos. It also inhibits in vitro M-phase-promoting factor activity and in vitro DNA synthesis in Xenopus egg extracts. A recent study shows that roscovitine inhibits Cdk5 kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum, without affecting the expression of Cdk5 protein during axenic growth. Roscovitine is an inhibitor of Cdk7, cyclin B, cyclin E, cyclin A, cyclin H, cdc2 and p53.Related product price
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