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ChemicalBook >> CAS DataBase List >> PFK-158

PFK-158

PFK-158 price.
  • $57 - $1470
  • Product name: PFK-158
  • CAS: 1462249-75-7
  • MF: C18H11F3N2O
  • MW: 328.29
  • EINECS:
  • MDL Number:
  • Synonyms:PFK-158;PFK-158, ACT-PFK-158;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;PFK-158;PFK 158;PFK-158 free base;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
12 prices
Selected condition：
Brand
  • AK Scientific
  • Axon Medchem
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2917DV
  • Product descriptionCID71730058
  • Packaging25mg
  • Price$343
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2542
  • Product descriptionPFK158 99%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22987
  • Product descriptionPFK158 ≥95%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22987
  • Product descriptionPFK158 ≥95%
  • Packaging10mg
  • Price$107
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22987
  • Product descriptionPFK158 ≥95%
  • Packaging25mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003416
  • Product descriptionPFK-158 98+%
  • Packaging5mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003416
  • Product descriptionPFK-158 98+%
  • Packaging10mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003416
  • Product descriptionPFK-158 98+%
  • Packaging50mg
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003416
  • Product descriptionPFK-158 98+%
  • Packaging100mg
  • Price$1470
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10451
  • Product descriptionPFK158 >98%
  • Packaging1g
  • Price$1350
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3145
  • Product descriptionPFK-158 ≥98% (HPLC)
  • Packaging5MG
  • Price$86.8
  • Updated2023-06-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3145
  • Product descriptionPFK-158 ≥98% (HPLC)
  • Packaging25MG
  • Price$280
  • Updated2023-06-20
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2917DV CID71730058 25mg $343 2021-12-16 Buy
Axon Medchem Axon2542 PFK158 99% 10mg $104.5 2021-12-16 Buy
Cayman Chemical 22987 PFK158 ≥95% 5mg $57 2024-03-01 Buy
Cayman Chemical 22987 PFK158 ≥95% 10mg $107 2024-03-01 Buy
Cayman Chemical 22987 PFK158 ≥95% 25mg $220 2024-03-01 Buy
Crysdot CD31003416 PFK-158 98+% 5mg $210 2021-12-16 Buy
Crysdot CD31003416 PFK-158 98+% 10mg $350 2021-12-16 Buy
Crysdot CD31003416 PFK-158 98+% 50mg $1050 2021-12-16 Buy
Crysdot CD31003416 PFK-158 98+% 100mg $1470 2021-12-16 Buy
DC Chemicals DC10451 PFK158 >98% 1g $1350 2021-12-16 Buy
Sigma-Aldrich SML3145 PFK-158 ≥98% (HPLC) 5MG $86.8 2023-06-20 Buy
Sigma-Aldrich SML3145 PFK-158 ≥98% (HPLC) 25MG $280 2023-06-20 Buy

Properties

Boiling point :466.3±45.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

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