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ChemicalBook >> CAS DataBase List >> Nordihydroguaiaretic acid

Nordihydroguaiaretic acid

Nordihydroguaiaretic acid price.
  • $15 - $1635
  • Product name: Nordihydroguaiaretic acid
  • CAS: 500-38-9
  • MF: C18H22O4
  • MW: 302.36
  • EINECS:207-903-0
  • MDL Number:MFCD00002206
  • Synonyms:Nordihydroguaiaretic acid,95%;[-CH(CH3)CH2C6H3-1,2-(OH)2]2;Nordihydroguaiaretic acid,1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol, Masoprocol, NDGA;Nordihydroguaiaretic acid, tech. 90%;To a dihydro-nordihydroguaiaretic acid;Nordihydroguaiaretic acid, 95% 500MG;Nordihydro Guaiaretic Acid (Mixture of diastereoMers);NSC 4291
39 prices
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 25mg
  • 100mg
  • 250mg
  • 500MG
  • 1g
  • 2g
  • 5g
  • 10g
  • 25g
  • ManufacturerAK Scientific
  • Product numberD419
  • Product description4,4'-(2,3-dimethyltetramethylene)dipyrocatechol(Nordihydroguaiareticacid)
  • Packaging25g
  • Price$1393
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL03149
  • Product descriptionNordihydroguaiaretic acid, 97%
  • Packaging1g
  • Price$80.4
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL03149
  • Product descriptionNordihydroguaiaretic acid, 97%
  • Packaging5g
  • Price$293
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA867405
  • Product description4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+%
  • Packaging25mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA867405
  • Product description4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+%
  • Packaging100mg
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA867405
  • Product description4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+%
  • Packaging250mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA867405
  • Product description4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+%
  • Packaging1g
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000262
  • Product descriptionNORDIHYDRO GUAIARETIC ACID 95.00%
  • Packaging500MG
  • Price$447.42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000262
  • Product descriptionNORDIHYDRO GUAIARETIC ACID 95.00%
  • Packaging1G
  • Price$478
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000262
  • Product descriptionNORDIHYDRO GUAIARETIC ACID 95.00%
  • Packaging5G
  • Price$693.24
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberXN163193
  • Product descriptionNordihydroguaiaretic acid - pure diastereomer
  • Packaging2g
  • Price$57
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFN26437
  • Product descriptionNordihydroguaiaretic acid - mixture of diastereomers
  • Packaging1g
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFN26437
  • Product descriptionNordihydroguaiaretic acid - mixture of diastereomers
  • Packaging2g
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberXN163193
  • Product descriptionNordihydroguaiaretic acid - pure diastereomer
  • Packaging5G
  • Price$137.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberXN163193
  • Product descriptionNordihydroguaiaretic acid - pure diastereomer
  • Packaging10g
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFN26437
  • Product descriptionNordihydroguaiaretic acid - mixture of diastereomers
  • Packaging5G
  • Price$270
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific D419 4,4'-(2,3-dimethyltetramethylene)dipyrocatechol(Nordihydroguaiareticacid) 25g $1393 2021-12-16 Buy
Alfa Aesar L03149 Nordihydroguaiaretic acid, 97% 1g $80.4 2024-03-01 Buy
Alfa Aesar L03149 Nordihydroguaiaretic acid, 97% 5g $293 2024-03-01 Buy
Ambeed A867405 4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+% 25mg $15 2021-12-16 Buy
Ambeed A867405 4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+% 100mg $32 2021-12-16 Buy
Ambeed A867405 4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+% 250mg $49 2021-12-16 Buy
Ambeed A867405 4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) 98+% 1g $121 2021-12-16 Buy
American Custom Chemicals Corporation INB0000262 NORDIHYDRO GUAIARETIC ACID 95.00% 500MG $447.42 2021-12-16 Buy
American Custom Chemicals Corporation INB0000262 NORDIHYDRO GUAIARETIC ACID 95.00% 1G $478 2021-12-16 Buy
American Custom Chemicals Corporation INB0000262 NORDIHYDRO GUAIARETIC ACID 95.00% 5G $693.24 2021-12-16 Buy
Biosynth Carbosynth XN163193 Nordihydroguaiaretic acid - pure diastereomer 2g $57 2021-12-16 Buy
Biosynth Carbosynth FN26437 Nordihydroguaiaretic acid - mixture of diastereomers 1g $80 2021-12-16 Buy
Biosynth Carbosynth FN26437 Nordihydroguaiaretic acid - mixture of diastereomers 2g $120 2021-12-16 Buy
Biosynth Carbosynth XN163193 Nordihydroguaiaretic acid - pure diastereomer 5G $137.5 2021-12-16 Buy
Biosynth Carbosynth XN163193 Nordihydroguaiaretic acid - pure diastereomer 10g $210 2021-12-16 Buy
Biosynth Carbosynth FN26437 Nordihydroguaiaretic acid - mixture of diastereomers 5G $270 2021-12-16 Buy

Properties

Melting point :184-186 °C (lit.)
Boiling point :363.4°C (rough estimate)
Density :1.0772 (rough estimate)
refractive index :1.4230 (estimate)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Powder
pka :9.56±0.10(Predicted)
color :White to off-white
Water Solubility :slightly soluble
Merck :14,6693
BRN :2056825
Stability :Stable. Incompatible with oxidizing agents.
LogP :4.640 (est)
CAS DataBase Reference :500-38-9(CAS DataBase Reference)
NIST Chemistry Reference :Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-(500-38-9)
EPA Substance Registry System :Nordihydroguaiaretic acid (500-38-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Nordihydroguaiaretic acid (NDGA) is a grayish-white crystalline compound that was widely used as an antioxidant in animal fats in the 1950s and 1960s. It possesses phenolic properties similar to gallates, including their advantages and disadvantages. Besides the isolation of natural material (resinous exudate of creosote bush), NDGA has also been chemically synthesized. As the result of unfavorable toxicological findings, NDGA is prohibited from use in the US. More specifically, NDGA is a potent lipoxygenase inhibitor which interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carbox- ylesterase,and,to a lesser extent, cyclooxygenase.

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