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ChemicalBook >> CAS DataBase List >> GSK-CXCR2

GSK-CXCR2

GSK-CXCR2 price.
  • $97 - $2230
  • Product name: GSK-CXCR2
  • CAS: 211096-49-0
  • MF: C14H9BrN6O
  • MW: 357.16
  • EINECS:
  • MDL Number:MFCD09971124
  • Synonyms:GSK-CXCR2;N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea;SB 265610;1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-;SB265610 >=98% (HPLC);CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
20 prices
Selected condition:
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1
  • 50
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number3699BB
  • Product descriptionN-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-YL)urea
  • Packaging10mg
  • Price$345
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3699BB
  • Product descriptionN-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-YL)urea
  • Packaging1mg
  • Price$206
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number211096490
  • Product description1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea
  • Packaging1g
  • Price$929.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number211096490
  • Product description1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea
  • Packaging5g
  • Price$2207.7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001078
  • Product descriptionSB-265610 95.00%
  • Packaging1MG
  • Price$617.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5333
  • Product descriptionSB265610
  • Packaging10mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17879
  • Product descriptionSB 265610 ≥98%
  • Packaging1mg
  • Price$97
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17879
  • Product descriptionSB 265610 ≥98%
  • Packaging5mg
  • Price$130
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17879
  • Product descriptionSB 265610 ≥98%
  • Packaging10mg
  • Price$223
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0004245
  • Product descriptionSB-265610 >99.0%
  • Packaging25mg
  • Price$1150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0004245
  • Product descriptionSB-265610 >99.0%
  • Packaging10mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11166715
  • Product description1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 97%
  • Packaging1g
  • Price$845
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11166715
  • Product description1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 97%
  • Packaging5g
  • Price$2230
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN23101
  • Product descriptionSB265610
  • Packaging25mg
  • Price$1070
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0421
  • Product descriptionSB265610 ≥98% (HPLC)
  • Packaging5mg
  • Price$160
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0421
  • Product descriptionSB265610 ≥98% (HPLC)
  • Packaging25mg
  • Price$642
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3699BB N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-YL)urea 10mg $345 2021-12-16 Buy
AK Scientific 3699BB N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-YL)urea 1mg $206 2021-12-16 Buy
Alichem 211096490 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 1g $929.5 2021-12-16 Buy
Alichem 211096490 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 5g $2207.7 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001078 SB-265610 95.00% 1MG $617.3 2021-12-16 Buy
ApexBio Technology B5333 SB265610 10mg $252 2021-12-16 Buy
Cayman Chemical 17879 SB 265610 ≥98% 1mg $97 2024-03-01 Buy
Cayman Chemical 17879 SB 265610 ≥98% 5mg $130 2024-03-01 Buy
Cayman Chemical 17879 SB 265610 ≥98% 10mg $223 2024-03-01 Buy
ChemScene CS-0004245 SB-265610 >99.0% 25mg $1150 2021-12-16 Buy
ChemScene CS-0004245 SB-265610 >99.0% 10mg $650 2021-12-16 Buy
Crysdot CD11166715 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 97% 1g $845 2021-12-16 Buy
Crysdot CD11166715 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea 97% 5g $2230 2021-12-16 Buy
CSNpharm CSN23101 SB265610 25mg $1070 2021-12-16 Buy
Sigma-Aldrich SML0421 SB265610 ≥98% (HPLC) 5mg $160 2024-03-01 Buy
Sigma-Aldrich SML0421 SB265610 ≥98% (HPLC) 25mg $642 2024-03-01 Buy

Properties

Boiling point :527.0±45.0 °C(Predicted)
Density :1.77±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble15mg/mL, clear
pka :6.13±0.40(Predicted)
form :powder
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and many other CXC chemokines involved in the trafficking and activation of inflammatory cells. It is involved in various inflammatory diseases, including chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis. SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor. It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.

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