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ChemicalBook >> CAS DataBase List >> Dimethyl fumarate

Dimethyl fumarate

Dimethyl fumarate price.
  • $5 - $685.21
  • Product name: Dimethyl fumarate
  • CAS: 624-49-7
  • MF: C6H8O4
  • MW: 144.13
  • EINECS:210-849-0
  • MDL Number:MFCD00064438
  • Synonyms:But-2-enedioicaciddimethylester;Fumaric acid, bis-methyl ester;Dimethyl furmarate;DiMethyl fuMarate, 99% 100GR;DiMethyl fuMarate, 99% 25GR;trans-butenedioicacid,dimethylester ;trans-butenedioicaciddimethylester ;Dimethyl fumarate,99%
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  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Frontier Specialty Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Usbiological
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  • 1kg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3701-G025
  • Product descriptionDimethyl fumarate ≥95%
  • Packaging25g
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF927
  • Product descriptionDimethyl fumarate
  • Packaging25g
  • Price$21.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA10402
  • Product descriptionDimethyl fumarate, 99%
  • Packaging25g
  • Price$29.7
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA10402
  • Product descriptionDimethyl fumarate, 99%
  • Packaging100g
  • Price$56.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA10402
  • Product descriptionDimethyl fumarate, 99%
  • Packaging250g
  • Price$102.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA258585
  • Product descriptionDimethyl fumarate 99%
  • Packaging10g
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA258585
  • Product descriptionDimethyl fumarate 99%
  • Packaging25g
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA258585
  • Product descriptionDimethyl fumarate 99%
  • Packaging100g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA258585
  • Product descriptionDimethyl fumarate 99%
  • Packaging500g
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA258585
  • Product descriptionDimethyl fumarate 99%
  • Packaging1kg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0006257
  • Product descriptionDIMETHYL FUMARATE 95.00%
  • Packaging1G
  • Price$136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0006257
  • Product descriptionDIMETHYL FUMARATE 95.00%
  • Packaging100MG
  • Price$685.21
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1931
  • Product descriptionDimethyl fumarate
  • Packaging5g
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS497427
  • Product descriptionDimethyl fumarate ≥99%
  • Packaging10g
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS497427
  • Product descriptionDimethyl fumarate ≥99%
  • Packaging25g
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS497427
  • Product descriptionDimethyl fumarate ≥99%
  • Packaging100g
  • Price$13
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3701-G025 Dimethyl fumarate ≥95% 25g $30 2021-12-16 Buy
AK Scientific F927 Dimethyl fumarate 25g $21.3 2021-12-16 Buy
Alfa Aesar A10402 Dimethyl fumarate, 99% 25g $29.7 2024-03-01 Buy
Alfa Aesar A10402 Dimethyl fumarate, 99% 100g $56.65 2024-03-01 Buy
Alfa Aesar A10402 Dimethyl fumarate, 99% 250g $102.65 2024-03-01 Buy
Ambeed A258585 Dimethyl fumarate 99% 10g $5 2021-12-16 Buy
Ambeed A258585 Dimethyl fumarate 99% 25g $7 2021-12-16 Buy
Ambeed A258585 Dimethyl fumarate 99% 100g $9 2021-12-16 Buy
Ambeed A258585 Dimethyl fumarate 99% 500g $24 2021-12-16 Buy
Ambeed A258585 Dimethyl fumarate 99% 1kg $45 2021-12-16 Buy
American Custom Chemicals Corporation API0006257 DIMETHYL FUMARATE 95.00% 1G $136.5 2021-12-16 Buy
American Custom Chemicals Corporation API0006257 DIMETHYL FUMARATE 95.00% 100MG $685.21 2021-12-16 Buy
ApexBio Technology B1931 Dimethyl fumarate 5g $52 2021-12-16 Buy
Arctom AS497427 Dimethyl fumarate ≥99% 10g $5 2021-12-16 Buy
Arctom AS497427 Dimethyl fumarate ≥99% 25g $7 2021-12-16 Buy
Arctom AS497427 Dimethyl fumarate ≥99% 100g $13 2021-12-16 Buy

Properties

Melting point :102-106 °C (lit.)
Boiling point :192-193 °C (lit.)
Density :1,37 g/cm3
vapor pressure :5 hPa (25 °C)
refractive index :1.4062 (estimate)
Flash point :192-193°C
storage temp. :Store below +30°C.
solubility :1.6g/l
form :Liquid
color :Clear colorless to faintly yellow
PH :4.0-6.0 (10g/l, H2O, 20℃)suspension
Water Solubility :Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck :14,4287
BRN :774590
Stability :Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
CAS DataBase Reference :624-49-7(CAS DataBase Reference)
NIST Chemistry Reference :2-Butenedioic acid (E)-, dimethyl ester(624-49-7)
EPA Substance Registry System :2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways. It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate. Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels. It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis. Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.

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