CARVEDILOL-D5
- $153 - $1455
- Product name: CARVEDILOL-D5
- CAS: 929106-58-1
- MF: C24H21D5N2O4
- MW: 411.51
- EINECS:
- MDL Number:MFCD08063416
- Synonyms:CARVEDILOL-D5;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5;Carvedilol-d5 N’-?-D-Glucuronide
6 prices
Selected condition:
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 5MG
- 10mg
- ManufacturerAK Scientific
- Product number8725DF
- Product descriptionCarvedilol-d5
- Packaging1mg
- Price$302
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0006704
- Product descriptionCARVEDILOL-D5 95.00%
- Packaging5MG
- Price$495.59
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25218
- Product descriptionCarvedilol-d5 ≥99% deuterated forms (d1-d5)
- Packaging500μg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25218
- Product descriptionCarvedilol-d5 ≥99% deuterated forms (d1-d5)
- Packaging1mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberC184628
- Product descriptionCarvedilol-d5
- Packaging10mg
- Price$1455
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number005808
- Product descriptionCarvedilol-d5
- Packaging1mg
- Price$460
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 8725DF | Carvedilol-d5 | 1mg | $302 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | RDL0006704 | CARVEDILOL-D5 95.00% | 5MG | $495.59 | 2021-12-16 | Buy |
Cayman Chemical | 25218 | Carvedilol-d5 ≥99% deuterated forms (d1-d5) | 500μg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 25218 | Carvedilol-d5 ≥99% deuterated forms (d1-d5) | 1mg | $184 | 2024-03-01 | Buy |
TRC | C184628 | Carvedilol-d5 | 10mg | $1455 | 2021-12-16 | Buy |
Usbiological | 005808 | Carvedilol-d5 | 1mg | $460 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
form :A solid
solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
form :A solid
Safety Information
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Description
Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.Related product price
- Metoprolol tartrate
$25-1593.9 - Carvedilol
$20-700
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