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    ChemicalBook >> CAS DataBase List >> CARVEDILOL-D5

    CARVEDILOL-D5

    CARVEDILOL-D5 price.
    • $153 - $1455
    • Product name: CARVEDILOL-D5
    • CAS: 929106-58-1
    • MF: C24H21D5N2O4
    • MW: 411.51
    • EINECS:
    • MDL Number:MFCD08063416
    • Synonyms:CARVEDILOL-D5;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5;Carvedilol-d5 N’-?-D-Glucuronide
    6 prices
    Selected condition:
    Brand
    • AK Scientific
    • American Custom Chemicals Corporation
    • Cayman Chemical
    • TRC
    • Usbiological
    Package
    • 500μg
    • 1mg
    • 5MG
    • 10mg
    • ManufacturerAK Scientific
    • Product number8725DF
    • Product descriptionCarvedilol-d5
    • Packaging1mg
    • Price$302
    • Updated2021-12-16
    • Buy
    • ManufacturerAmerican Custom Chemicals Corporation
    • Product numberRDL0006704
    • Product descriptionCARVEDILOL-D5 95.00%
    • Packaging5MG
    • Price$495.59
    • Updated2021-12-16
    • Buy
    • ManufacturerCayman Chemical
    • Product number25218
    • Product descriptionCarvedilol-d5 ≥99% deuterated forms (d1-d5)
    • Packaging500μg
    • Price$153
    • Updated2024-03-01
    • Buy
    • ManufacturerCayman Chemical
    • Product number25218
    • Product descriptionCarvedilol-d5 ≥99% deuterated forms (d1-d5)
    • Packaging1mg
    • Price$184
    • Updated2024-03-01
    • Buy
    • ManufacturerTRC
    • Product numberC184628
    • Product descriptionCarvedilol-d5
    • Packaging10mg
    • Price$1455
    • Updated2021-12-16
    • Buy
    • ManufacturerUsbiological
    • Product number005808
    • Product descriptionCarvedilol-d5
    • Packaging1mg
    • Price$460
    • Updated2021-12-16
    • Buy
    Manufacturer Product number Product description Packaging Price Updated Buy
    AK Scientific 8725DF Carvedilol-d5 1mg $302 2021-12-16 Buy
    American Custom Chemicals Corporation RDL0006704 CARVEDILOL-D5 95.00% 5MG $495.59 2021-12-16 Buy
    Cayman Chemical 25218 Carvedilol-d5 ≥99% deuterated forms (d1-d5) 500μg $153 2024-03-01 Buy
    Cayman Chemical 25218 Carvedilol-d5 ≥99% deuterated forms (d1-d5) 1mg $184 2024-03-01 Buy
    TRC C184628 Carvedilol-d5 10mg $1455 2021-12-16 Buy
    Usbiological 005808 Carvedilol-d5 1mg $460 2021-12-16 Buy

    Properties

    storage temp. :Store at -20°C
    solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
    form :A solid

    Safety Information

    Symbol(GHS): GHS hazard pictograms
    Signal word:
    Hazard statements:
    Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
    H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
    H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
    Precautionary statements:
    P273 Avoid release to the environment.
    P391 Collect spillage. Hazardous to the aquatic environment
    P501 Dispose of contents/container to..…

    Description

    Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.

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