Almotriptan
- $35 - $1550
- Product name: Almotriptan
- CAS: 154323-57-6
- MF: C17H25N3O2S
- MW: 335.46
- EINECS:1312995-182-4
- MDL Number:MFCD00927104
- Synonyms:LAS-31416-d6;ALMOTRIPTAN(SUBJECTTOPATENETFREE);Almotriptan;N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine;dimethyl-[2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethyl]amine;AlMotriptan API;N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine;ALMOTRIPTAN-D6
17 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- AvaChem
- Biorbyt Ltd
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Usbiological
Package
- 5MG
- Y0002140
- 1mg
- 10mg
- 25mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0006650
- Product descriptionALMOTRIPTAN-D6 95.00%
- Packaging5MG
- Price$497.17
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3080B
- Product descriptionAlmotriptan
- Packaging5mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3080B
- Product descriptionAlmotriptan
- Packaging25mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3080B
- Product descriptionAlmotriptan
- Packaging100mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3080B
- Product descriptionAlmotriptan
- Packaging1g
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134783
- Product descriptionAlmotriptan >99%
- Packaging100mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134783
- Product descriptionAlmotriptan >99%
- Packaging250mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134783
- Product descriptionAlmotriptan >99%
- Packaging1g
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDCAPI1478
- Product descriptionAlmotriptan >99%
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDCAPI1478
- Product descriptionAlmotriptan >99%
- Packaging250mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDCAPI1478
- Product descriptionAlmotriptan >99%
- Packaging1g
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number091207
- Product descriptionN,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+%
- Packaging250mg
- Price$184
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number091207
- Product descriptionN,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+%
- Packaging1g
- Price$457
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product numberD33837
- Product descriptionAlmotriptan-d3Benzoate
- Packaging1mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product numberD33837
- Product descriptionAlmotriptan-d3Benzoate
- Packaging5mg
- Price$1550
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberY0002140
- Product descriptionAlmotriptan for system suitability CRS, European Pharmacopoeia (EP) Reference Standard
- PackagingY0002140
- Price$156
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | RDL0006650 | ALMOTRIPTAN-D6 95.00% | 5MG | $497.17 | 2021-12-16 | Buy |
AvaChem | 3080B | Almotriptan | 5mg | $35 | 2021-12-16 | Buy |
AvaChem | 3080B | Almotriptan | 25mg | $85 | 2021-12-16 | Buy |
AvaChem | 3080B | Almotriptan | 100mg | $179 | 2021-12-16 | Buy |
AvaChem | 3080B | Almotriptan | 1g | $690 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134783 | Almotriptan >99% | 100mg | $510 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134783 | Almotriptan >99% | 250mg | $606.9 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134783 | Almotriptan >99% | 1g | $1504.5 | 2021-12-16 | Buy |
DC Chemicals | DCAPI1478 | Almotriptan >99% | 100mg | $250 | 2021-12-16 | Buy |
DC Chemicals | DCAPI1478 | Almotriptan >99% | 250mg | $300 | 2021-12-16 | Buy |
DC Chemicals | DCAPI1478 | Almotriptan >99% | 1g | $1000 | 2021-12-16 | Buy |
Matrix Scientific | 091207 | N,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+% | 250mg | $184 | 2021-12-16 | Buy |
Matrix Scientific | 091207 | N,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine 95+% | 1g | $457 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D33837 | Almotriptan-d3Benzoate | 1mg | $640 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D33837 | Almotriptan-d3Benzoate | 5mg | $1550 | 2021-12-16 | Buy |
Sigma-Aldrich | Y0002140 | Almotriptan for system suitability CRS, European Pharmacopoeia (EP) Reference Standard | Y0002140 | $156 | 2024-03-01 | Buy |
Properties
Boiling point :538.7±60.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
pka :16.92±0.30(Predicted)
form :Solid
color :White to off-white
CAS DataBase Reference :154323-57-6(CAS DataBase Reference)
Density :1.27±0.1 g/cm3(Predicted)
pka :16.92±0.30(Predicted)
form :Solid
color :White to off-white
CAS DataBase Reference :154323-57-6(CAS DataBase Reference)
Safety Information
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Description
Almotriptan was first marketed in Spain as a new medicine against acute attacks of migraine. It is the fifth agent belonging to the “triptan” class to be launched after sumatriptan, naratriptan, zolmitriptan and rizatriptan. This close structural analog of sumatriptan can be prepared in six steps from 4-nitrobenzylsulfonyl chloride with a Fischer indole synthesis as the key step. Almotriptan acts as a dual 5-HT1D/1B agonist with a 35 to 51-fold selectivity versus 5-HT1A and 5-HT7 receptors respectively as well as having insignificant affinity for the most relevant nonserotonergic receptors (K1>1μM). Its agonistic effect on 5-HT,n receptors of trigeminal sensory neurons turns off neurogenic inflammation by inhibiting the release of neuropeptides such as calcitonin gene-related peptide, neurokinin A and substance P. Concomitantly, its action on the 5-HT1B receptors in meningeal arteries relieves the vasodilatation of these vessels associated with migraine attacks. Almotriptan causes selective concentration-dependent vasoconstriction of human meningeal and temporal arteries (with EC50 of 0.03 and 0.7 μM) compared to basilar (EC50 = 3.5 μM) and pulmonary arteries (EC50>10μM) or rabbit mesenteric and renal arteries (EC50>100 μM). Although it is predominantly cleared by the kidneys as unchanged drug (45%) or transformed into inactive metabolites by monoamine oxidase A (MAO-A) and CYP3A4 enzymes in the liver, almotriptan has the highest oral bioavailability (70%) of the triptans and has a half-life of 3.5 h. The therapeutic dose of 12.5 mg is well tolerated, shows a rapid onset of action (30 min) and low recurrence rate compared to sumatriptan.More related product prices
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