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ChemicalBook >> CAS DataBase List >> L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID

L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID

L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID price.
  • $32 - $1170.31
  • Product name: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID
  • CAS: 64769-66-0
  • MF: C6H9NO4
  • MW: 159.14
  • EINECS:
  • MDL Number:MFCD00153866
  • Synonyms:L-TRANS-4-CARBOXY-L-PROLINE;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;L-TRANS-2,4-PDC;TRANS-4-CARBOXY-L-PROLINE;2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI);Zinc03796127;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid
14 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 2mg
  • 1mg
  • 50
  • 2.5mg
  • 5MG
  • 10MG
  • 50MG
  • ManufacturerAK Scientific
  • Product number9449BA
  • Product descriptiontrans-4-Carboxy-L-proline
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging50MG
  • Price$1170.31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging10MG
  • Price$697.34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging5MG
  • Price$232.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6250
  • Product descriptionL-trans-2,4-PDC
  • Packaging10mg
  • Price$251
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6250
  • Product descriptionL-trans-2,4-PDC
  • Packaging50mg
  • Price$1053
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number24268
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number24268
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98%
  • Packaging5mg
  • Price$78
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging2mg
  • Price$72.8
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging10mg
  • Price$232
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number0298
  • Product descriptionL-trans-2,4-PDC ≥97%(HPLC)
  • Packaging10
  • Price$169
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number0298
  • Product descriptionL-trans-2,4-PDC ≥97%(HPLC)
  • Packaging50
  • Price$711
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP999005
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid
  • Packaging2.5mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number255657
  • Product descriptionL-trans-2,4-PDC
  • Packaging10mg
  • Price$423
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9449BA trans-4-Carboxy-L-proline 1mg $133 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 50MG $1170.31 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 10MG $697.34 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 5MG $232.1 2021-12-16 Buy
ApexBio Technology B6250 L-trans-2,4-PDC 10mg $251 2021-12-16 Buy
ApexBio Technology B6250 L-trans-2,4-PDC 50mg $1053 2021-12-16 Buy
Cayman Chemical 24268 L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 24268 L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% 5mg $78 2024-03-01 Buy
Sigma-Aldrich P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 2mg $72.8 2024-03-01 Buy
Sigma-Aldrich P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 10mg $232 2024-03-01 Buy
Tocris 0298 L-trans-2,4-PDC ≥97%(HPLC) 10 $169 2021-12-16 Buy
Tocris 0298 L-trans-2,4-PDC ≥97%(HPLC) 50 $711 2021-12-16 Buy
TRC P999005 L-trans-Pyrrolidine-2,4-dicarboxylic acid 2.5mg $195 2021-12-16 Buy
Usbiological 255657 L-trans-2,4-PDC 10mg $423 2021-12-16 Buy

Properties

Melting point :214-217oC
storage temp. :Store at RT
solubility :Water (Slightly)
form :White solid.
color :White
Water Solubility :Soluble to 100 mM in water

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-PDC is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-PDC has a correlated effect of inducing neuronal Ca2+ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-PDC for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.

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